Fluorination of 2-substituted benzo[b]furans with Selectfluor™

被引：23
作者：
Wang, Mingliang [1 ]
Liu, Xixi [1 ]
Zhou, Lu [2 ]
Zhu, Jidong [3 ]
Sun, Xun [1 ,4 ]
机构：
[1] Fudan Univ, Dept Nat Prod Chem, Shanghai 201203, Peoples R China
[2] Fudan Univ, Dept Med Chem, Shanghai 201203, Peoples R China
[3] Chinese Acad Sci, Interdisciplinary Res Ctr Biol & Chem, Shanghai 200032, Peoples R China
[4] Shanghai Key Lab Clin Geriatr Med, Shanghai 200040, Peoples R China
来源：
ORGANIC & BIOMOLECULAR CHEMISTRY | 2015年 / 13卷 / 11期
基金：
中国国家自然科学基金;
关键词：
ENANTIOSELECTIVE FLUORINATION; 2-ALKYNYLANILINES; DERIVATIVES; AMINOFLUORINATION; CYCLIZATION; CHEMISTRY; OXINDOLES; INDOLES; ANALOGS; DRUGS;
D O I：
10.1039/c4ob02691h
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
An efficient protocol was developed to access 3-fluoro-2-hydroxy-2-substituted benzo[b]furans with Selectfluor (TM) as the fluorinating reagent in MeCN and water. By utilizing SOCl2/Py as the dehydrating agent, the compounds above were readily converted to 3-fluorinated, 2-substituted benzo[b]furans in high yields.
引用
收藏
页码：3190 / 3193
页数：4
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