Simultaneous quantitation of parabens, triclosan, and methyl triclosan in indoor house dust using solid phase extraction and gas chromatography-mass spectrometry

被引:49
作者
Fan, Xinghua [1 ]
Kubwabo, Cariton [1 ]
Rasmussen, Pat [1 ]
Jones-Otazo, Heather [2 ]
机构
[1] Hlth Canada, Healthy Environm & Consumer Safety Branch, Environm Hlth Sci & Res Bur, Ottawa, ON K1A 0K9, Canada
[2] Hlth Canada, Reg & Programs Branch, Environm Hlth Program, Toronto, ON M5V 3L7, Canada
来源
JOURNAL OF ENVIRONMENTAL MONITORING | 2010年 / 12卷 / 10期
关键词
WASTE-WATER TREATMENT; HPLC-MS/MS METHOD; PERSONAL-CARE PRODUCTS; ENVIRONMENTAL PHENOLS; LIQUID-CHROMATOGRAPHY; SURFACE WATERS; URINARY CONCENTRATIONS; BACTERICIDE TRICLOSAN; AQUATIC ENVIRONMENT; TREATMENT PLANTS;
D O I
10.1039/c0em00189a
中图分类号
O65 [分析化学];
学科分类号
070302 ; 081704 ;
摘要
An integrated analytical method for the simultaneous determination of five parabens (methyl-, ethyl-, propyl-, butyl-, and benzyl-), triclosan, and methyl triclosan in indoor house dust was developed based on gas chromatographic-mass spectrometric technique (GC/MS). Analytes were extracted from dust samples by sonication. After sample cleanup by solid-phase extraction (SPE), the extracts were derivatized with N-methyl-N-(trimethylsilyl) trifluoroacetamide (MSTFA) and then analyzed by gas chromatography coupled with ion trap mass spectrometry operated in multiple reaction monitoring (MRM) mode. For quantitation, isotope-labelled internal standards were used for each corresponding target analyte. Only 0.05 g of dust sample was needed for the analysis. Method detection limits ranged from 6.5 to 10 ng/g, and absolute recoveries from 74% to 92%. The developed method demonstrated good repeatability and reproducibility, with relative standard deviations (RSDs) less than 16% for all the analytes. The analytes were determined in dust samples collected using two vacuum sampling methods from 63 Canadian homes: a sample of fresh or "active'' dust (FD) collected using a Pullman-Holt vacuum sampler, and a composite sample taken from the household vacuum cleaner (HD). Methyl paraben, propyl paraben, and triclosan were detected in all HD and FD samples. HD samples yielded median values for methyl paraben, propyl paraben, and triclosan of 1080, 463, and 378 ng/g, respectively, which were comparable to the FD sample medians of 1120, 618 and 571 ng/g. Ethyl paraben was detected at frequencies of 89% in FD and 73% in HD samples, with median values of 52 and 25 ng/g, respectively. Butyl paraben was detected at frequencies of 44% in FD and 75% in HD samples, with median values of <10 and 59 ng/g, respectively. Benzyl paraben and methyl triclosan were not detected in any of the samples collected by either method. Samples collected according to the fresh dust protocol agreed with the household vacuum samples 90% of the time. Widely scattered concentration levels were observed for target analytes from this preliminary set of 63 Canadian samples, which suggests a wide variability in Canadian household exposures to these chemicals.
引用
收藏
页码:1891 / 1897
页数:7
相关论文
共 47 条
  • [1] Triclosan, a commonly used bactericide found in human milk and in the aquatic environment in Sweden
    Adolfsson-Erici, M
    Pettersson, M
    Parkkonen, J
    Sturve, J
    [J]. CHEMOSPHERE, 2002, 46 (9-10) : 1485 - 1489
  • [2] Triclosan in plasma and milk from Swedish nursing mothers and their exposure via personal care products
    Allmyr, Mats
    Adolfsson-Erici, Margaretha
    McLachlan, Michael S.
    Sandborgh-Englund, Gunilla
    [J]. SCIENCE OF THE TOTAL ENVIRONMENT, 2006, 372 (01) : 87 - 93
  • [3] Occurrence of methyl triclosan, a transformation product of the bactericide triclosan, in fish from various lakes in Switzerland
    Balmer, ME
    Poiger, T
    Droz, C
    Romanin, K
    Bergqvist, PA
    Müller, MD
    Buser, HR
    [J]. ENVIRONMENTAL SCIENCE & TECHNOLOGY, 2004, 38 (02) : 390 - 395
  • [4] Fate of triclosan and triclosan-methyl in sewage treatment plants and surface waters
    Bester, K
    [J]. ARCHIVES OF ENVIRONMENTAL CONTAMINATION AND TOXICOLOGY, 2005, 49 (01) : 9 - 17
  • [5] Boehmer W.R., 2004, ORGANOHALOGEN COMP, V66, P1516
  • [6] Selective enzyme-linked Immunosorbent assay for triclosan. Application to wastewater treatment plant effluents
    Brun, Eva M.
    Bonet, Emilio
    Puchades, Rosa
    Maquieira, Angel
    [J]. ENVIRONMENTAL SCIENCE & TECHNOLOGY, 2008, 42 (05) : 1665 - 1672
  • [7] Urinary concentrations of Triclosan in the US population: 2003-2004
    Calafat, Antonia M.
    Ye, Xiaoyun
    Wong, Lee-Yang
    Reidy, John A.
    Needham, Larry L.
    [J]. ENVIRONMENTAL HEALTH PERSPECTIVES, 2008, 116 (03) : 303 - 307
  • [8] Simplified sample preparation method for triclosan and methyltriclosan determination in biota and foodstuff samples
    Canosa, P.
    Rodriguez, I.
    Rubi, E.
    Ramil, M.
    Cela, R.
    [J]. JOURNAL OF CHROMATOGRAPHY A, 2008, 1188 (02) : 132 - 139
  • [9] Pressurized liquid extraction with in-cell clean-up followed by gas chromatography-tandem mass spectrometry for the selective determination of parabens and triclosan in indoor dust
    Canosa, P.
    Perez-Palacios, D.
    Garrido-Lopez, A.
    Tena, M. T.
    Rodriguez, I.
    Rubi, E.
    Cela, R.
    [J]. JOURNAL OF CHROMATOGRAPHY A, 2007, 1161 (1-2) : 105 - 112
  • [10] Determination of parabens and triclosan in indoor dust using matrix solid-phase dispersion and gas chromatography with tandem mass spectrometry
    Canosa, P.
    Rodriguez, I.
    Rubi, E.
    Cela, R.
    [J]. ANALYTICAL CHEMISTRY, 2007, 79 (04) : 1675 - 1681