In vitro release of levonorgestrel from phase sensitive and thermosensitive smart polymer delivery systems

被引:33
作者
Chen, SB [1 ]
Singh, J [1 ]
机构
[1] N Dakota State Univ, Coll Pharm, Dept Pharmaceut Sci, Fargo, ND 58105 USA
关键词
levonorgestrel; contraceptive hormone; phase sensitive; thermosensitive; biodegradable polymers;
D O I
10.1081/PDT-200054479
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
The objective of this research is to develop injectable controlled delivery systems for the contraceptive hormone, levonorgestrel (LNG), using phase sensitive and thermosensitive polymers. A combination of poly (lactide) (PLA) and a solvent mixture of benzyl benzoate (BB) and benzyl alcohol (BA) was used in the phase-sensitive polymer delivery systems. The effects of solvent systems and polymer concentrations on the in vitro LNG release were evaluated. In the case of thermosensitive polymer delivery systems, a series of low-molecular-weight poly (lactide-co-glycolide)-poly (ethyleneglycol)-poly (lactide-co-glycolide) (PLGA-PEG-PLGA) triblock copolymers with varying ratios of lactide/glycolide (LA/GA, 2.0-3.5) were used. The effects of varying block length of copolymers 1, 2, 3, and 4 on the in vitro LNG release were evaluated. Phosphate buffer saline (pH 7.4) containing 0.5% w/v Tween-80 was used as in vitro release medium. The amount of the released LNG was determined by an high pressure liquid chromatography (HPLC) method. A controlled (zero-order) in vitro release of LNG was observed from both phase-sensitive and thermosensitive-polymer delivery systems. Increasing the concentration of the phase-sensitive polymer from 5% to 30% significantly (p<0.05) decreased the release rate of LNG from 38.32 mu g/day to 31.45 mu g/day; and increasing the hydrophilic fraction of the solvents mixture (i.e., BA) significantly (p<0.05) increased the release rate of LNG. In the case of the thermosensitive polymer delivery system, increasing the hydrophobic PLGA block length of copolymers significantly (p<0.05) decreased the release rate of LNG (98.65 mu g/day to 67.60 mu g/day). It is evident from this study that both the phase sensitive and thermosensitive polymers are suitable for developing prolonged-release injectable delivery systems for the contraceptive hormone.
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页码:319 / 325
页数:7
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