Emerging treatments for inflammatory bowel disease

被引:140
作者
Hazel, Karl [1 ]
O'Connor, Anthony [2 ,3 ]
机构
[1] Tallaght Univ Hosp, Dept Gastroenterol, Belgard Rd, Dublin D24 NR0A, Ireland
[2] Tallaght Univ Hosp, Ctr Inflammatory Bowel Dis, Dublin, Ireland
[3] Univ Dublin, Trinity Coll, Dublin, Ireland
关键词
Crohn's disease; inflammatory bowel disease; ulcerative colitis; REFRACTORY CROHNS-DISEASE; STEM-CELL TRANSPLANTATION; FECAL MICROBIOTA TRANSPLANTATION; ACTIVE ULCERATIVE-COLITIS; MAINTENANCE THERAPY; INDUCTION THERAPY; DOUBLE-BLIND; ANTIBODY; TOFACITINIB; VEDOLIZUMAB;
D O I
10.1177/2040622319899297
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
Inflammatory bowel disease (IBD), including Crohn's disease (CD) and ulcerative colitis (UC), is characterized by chronic inflammation, a relapsing and remitting clinical course, requirement for lifelong medication and often, significant morbidity. While multiple effective therapeutic options exist for the treatment of IBD, a proportion of patients will either fail to respond or lose response to therapy. Advances in therapeutics, such as the gut-specific anti-integrins, now offer patients an alternative option to systemic immunosuppression. Anti-interleukin 12 (anti-IL-12)/IL-23 agents offer new and effective treatment options for CD, while the oral small molecules now offer an oral alternative for the treatment of moderate-to-severe disease, previously requiring subcutaneous injection or intravenous infusion. Alternatives to pharmacological treatment such as stem-cell transplant and faecal microbiota transplant are also showing some promise in the treatment of both CD and UC.
引用
收藏
页数:12
相关论文
共 83 条
[11]   Mesenchymal stem cells reside in virtually all post-natal organs and tissues [J].
da Silva Meirelles, Lindolfo ;
Chagastelles, Pedro Cesar ;
Nardi, Nance Beyer .
JOURNAL OF CELL SCIENCE, 2006, 119 (11) :2204-2213
[12]  
Danese S, 2018, J CROHNS COLITIS, V12, pS4
[13]   JAK inhibition using tofacitinib for inflammatory bowel disease treatment: a hub for multiple inflammatory cytokines [J].
Danese, Silvio ;
Grisham, Matthew ;
Hodge, Jennifer ;
Telliez, Jean-Baptiste .
AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY, 2016, 310 (03) :G155-G162
[14]   Biological Agents for Moderately to Severely Active Ulcerative Colitis A Systematic Review and Network Meta-analysis [J].
Danese, Silvio ;
Fiorino, Gionata ;
Peyrin-Biroulet, Laurent ;
Lucenteforte, Ersilia ;
Virgili, Gianni ;
Moja, Lorenzo ;
Bonovas, Stefanos .
ANNALS OF INTERNAL MEDICINE, 2014, 160 (10) :704-+
[15]   Transient Flare of Ulcerative Colitis After Fecal Microbiota Transplantation for Recurrent Clostridium difficile Infection [J].
De Leon, Lauren M. ;
Watson, James B. ;
Kelly, Colleen R. .
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY, 2013, 11 (08) :1036-1038
[16]   S1 pping fire: Sphingosine-1-phosphate signaling as an emerging target in inflammatory bowel disease and colitis-associated cancer [J].
Degagne, Emilie ;
Saba, Julie D. .
CLINICAL AND EXPERIMENTAL GASTROENTEROLOGY, 2014, 7 :205-214
[17]   The safety of autologous and metabolically fit bone marrow mesenchymal stromal cells in medically refractory Crohn's disease - a phase 1 trial with three doses [J].
Dhere, T. ;
Copland, I. ;
Garcia, M. ;
Chiang, K. Y. ;
Chinnadurai, R. ;
Prasad, M. ;
Galipeau, J. ;
Kugathasan, S. .
ALIMENTARY PHARMACOLOGY & THERAPEUTICS, 2016, 44 (05) :471-481
[18]   Autologous Mesenchymal Stem Cells, Applied in a Bioabsorbable Matrix, for Treatment of Perianal Fistulas in Patients With Crohn's Disease [J].
Dietz, Allan B. ;
Dozois, Eric J. ;
Fletcher, Joel G. ;
Butler, Greg W. ;
Radel, Darcie ;
Lightner, Amy L. ;
Dave, Maneesh ;
Friton, Jessica ;
Nair, Asha ;
Camilleri, Emily T. ;
Dudakovic, Amel ;
Van Wijnen, Andre J. ;
Faubion, William A. .
GASTROENTEROLOGY, 2017, 153 (01) :59-+
[19]   Autologous bone marrow-derived mesenchymal stromal cell treatment for refractory luminal Crohn's disease: results of a phase I study [J].
Duijvestein, Marjolijn ;
Vos, Anne Christine W. ;
Roelofs, Helene ;
Wildenberg, Manon E. ;
Wendrich, Barbara B. ;
Verspaget, Henricus W. ;
Kooy-Winkelaar, Engelina M. C. ;
Koning, Frits ;
Zwaginga, Jaap Jan ;
Fidder, Herma H. ;
Verhaar, Auke P. ;
Fibbe, Willem E. ;
van den Brink, Gijs R. ;
Hommes, Daniel W. .
GUT, 2010, 59 (12) :1662-1669
[20]   Anti-inflammatory activities of cAMP-elevating agents: enhancement of IL-10 synthesis and concurrent suppression of TNF production [J].
Eigler, A ;
Siegmund, B ;
Emmerich, U ;
Baumann, KH ;
Hartmann, G ;
Endres, S .
JOURNAL OF LEUKOCYTE BIOLOGY, 1998, 63 (01) :101-107