共 30 条
Chemoenzymatic methods for site-specific protein modification
被引:93
作者:

Rabuka, David
论文数: 0 引用数: 0
h-index: 0
机构:
Redwood Biosci, Burlingame, CA 94010 USA Redwood Biosci, Burlingame, CA 94010 USA
机构:
[1] Redwood Biosci, Burlingame, CA 94010 USA
基金:
美国国家卫生研究院;
关键词:
SMALL-MOLECULE PROBES;
IN-VITRO;
LIVING CELLS;
MONOCLONAL-ANTIBODIES;
FUSION PROTEINS;
QUANTUM DOTS;
ALDEHYDE TAG;
CONJUGATION;
SURFACE;
LIGASE;
D O I:
10.1016/j.cbpa.2010.09.020
中图分类号:
Q5 [生物化学];
Q7 [分子生物学];
学科分类号:
071010 ;
081704 ;
摘要:
In the past decade, numerous chemical technologies have been developed to allow the site-specific post-translational modification of proteins. Traditionally covalent chemical protein modification has been accomplished by the attachment of synthetic groups to nucleophilic amino acids on protein surfaces. These chemistries, however, are rarely sufficiently selective to distinguish one residue within a literal sea of chemical functionality. One solution to this problem is to introduce a unique chemical handle into the target protein that is orthogonal to the remainder of the proteome. In practice, this handle can be a novel peptide sequence, which forms a 'tag' that is selectively and irreversibly modified by enzymes. Furthermore, if the enzymes can tolerate substrate analogs, it becomes possible to engineer chemically modified proteins in a site-specific fashion. This review details the significant progress in creating techniques for the chemoenzymatic generation of protein-small molecule constructs and provides examples of novel applications of these methodologies.
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页码:790 / 796
页数:7
相关论文
共 30 条
[1]
Site-Specific N- and C-Terminal Labeling of a Single Polypeptide Using Sortases of Different Specificity
[J].
Antos, John M.
;
Chew, Guo-Liang
;
Guimaraes, Carla P.
;
Yoder, Nicholas C.
;
Grotenbreg, Gijsbert M.
;
Popp, Maximilian Wei-Lin
;
Ploegh, Hidde L.
.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY,
2009, 131 (31)
:10800-+

Antos, John M.
论文数: 0 引用数: 0
h-index: 0
机构:
Whitehead Inst Biomed Res, Cambridge, MA 02142 USA Whitehead Inst Biomed Res, Cambridge, MA 02142 USA

Chew, Guo-Liang
论文数: 0 引用数: 0
h-index: 0
机构:
Whitehead Inst Biomed Res, Cambridge, MA 02142 USA Whitehead Inst Biomed Res, Cambridge, MA 02142 USA

Guimaraes, Carla P.
论文数: 0 引用数: 0
h-index: 0
机构:
Whitehead Inst Biomed Res, Cambridge, MA 02142 USA Whitehead Inst Biomed Res, Cambridge, MA 02142 USA

Yoder, Nicholas C.
论文数: 0 引用数: 0
h-index: 0
机构:
Whitehead Inst Biomed Res, Cambridge, MA 02142 USA Whitehead Inst Biomed Res, Cambridge, MA 02142 USA

Grotenbreg, Gijsbert M.
论文数: 0 引用数: 0
h-index: 0
机构:
Whitehead Inst Biomed Res, Cambridge, MA 02142 USA Whitehead Inst Biomed Res, Cambridge, MA 02142 USA

Popp, Maximilian Wei-Lin
论文数: 0 引用数: 0
h-index: 0
机构:
Whitehead Inst Biomed Res, Cambridge, MA 02142 USA Whitehead Inst Biomed Res, Cambridge, MA 02142 USA

Ploegh, Hidde L.
论文数: 0 引用数: 0
h-index: 0
机构:
Whitehead Inst Biomed Res, Cambridge, MA 02142 USA Whitehead Inst Biomed Res, Cambridge, MA 02142 USA
[2]
Lipid Modification of Proteins through Sortase-Catalyzed Transpeptidation
[J].
Antos, John M.
;
Miller, Gwenn M.
;
Grotenbreg, Gijsbert M.
;
Ploegh, Hidde L.
.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY,
2008, 130 (48)
:16338-16343

Antos, John M.
论文数: 0 引用数: 0
h-index: 0
机构:
Whitehead Inst Biomed Res, Cambridge, MA 02142 USA Whitehead Inst Biomed Res, Cambridge, MA 02142 USA

Miller, Gwenn M.
论文数: 0 引用数: 0
h-index: 0
机构:
Whitehead Inst Biomed Res, Cambridge, MA 02142 USA Whitehead Inst Biomed Res, Cambridge, MA 02142 USA

Grotenbreg, Gijsbert M.
论文数: 0 引用数: 0
h-index: 0
机构:
Whitehead Inst Biomed Res, Cambridge, MA 02142 USA Whitehead Inst Biomed Res, Cambridge, MA 02142 USA

Ploegh, Hidde L.
论文数: 0 引用数: 0
h-index: 0
机构:
Whitehead Inst Biomed Res, Cambridge, MA 02142 USA Whitehead Inst Biomed Res, Cambridge, MA 02142 USA
[3]
Site Specific Conjugation of Fluoroprobes to the Remodeled Fc N-Glycans of Monoclonal Antibodies Using Mutant Glycosyltransferases: Application for Cell Surface Antigen Detection
[J].
Boeggeman, Elizabeth
;
Ramakrishnan, Boopathy
;
Pasek, Marta
;
Manzoni, Maria
;
Puri, Anu
;
Loomis, Kristin H.
;
Waybright, Timothy J.
;
Qasba, Pradman K.
.
BIOCONJUGATE CHEMISTRY,
2009, 20 (06)
:1228-1236

Boeggeman, Elizabeth
论文数: 0 引用数: 0
h-index: 0
机构:
SAIC Frederick Inc, Struct Glycobiol Sect, CCR Nanobiol Program, Frederick, MD USA
SAIC Frederick Inc, Membrane Struct & Funct Sect, CCR Nanobiol Program, Frederick, MD USA
SAIC Frederick Inc, Basic Res Program, Frederick, MD USA SAIC Frederick Inc, Struct Glycobiol Sect, CCR Nanobiol Program, Frederick, MD USA

Ramakrishnan, Boopathy
论文数: 0 引用数: 0
h-index: 0
机构:
SAIC Frederick Inc, Struct Glycobiol Sect, CCR Nanobiol Program, Frederick, MD USA
SAIC Frederick Inc, Membrane Struct & Funct Sect, CCR Nanobiol Program, Frederick, MD USA
SAIC Frederick Inc, Basic Res Program, Frederick, MD USA SAIC Frederick Inc, Struct Glycobiol Sect, CCR Nanobiol Program, Frederick, MD USA

Pasek, Marta
论文数: 0 引用数: 0
h-index: 0
机构:
SAIC Frederick Inc, Struct Glycobiol Sect, CCR Nanobiol Program, Frederick, MD USA SAIC Frederick Inc, Struct Glycobiol Sect, CCR Nanobiol Program, Frederick, MD USA

Manzoni, Maria
论文数: 0 引用数: 0
h-index: 0
机构:
SAIC Frederick Inc, Struct Glycobiol Sect, CCR Nanobiol Program, Frederick, MD USA SAIC Frederick Inc, Struct Glycobiol Sect, CCR Nanobiol Program, Frederick, MD USA

Puri, Anu
论文数: 0 引用数: 0
h-index: 0
机构:
SAIC Frederick Inc, Membrane Struct & Funct Sect, CCR Nanobiol Program, Frederick, MD USA SAIC Frederick Inc, Struct Glycobiol Sect, CCR Nanobiol Program, Frederick, MD USA

Loomis, Kristin H.
论文数: 0 引用数: 0
h-index: 0
机构:
SAIC Frederick Inc, Membrane Struct & Funct Sect, CCR Nanobiol Program, Frederick, MD USA SAIC Frederick Inc, Struct Glycobiol Sect, CCR Nanobiol Program, Frederick, MD USA

Waybright, Timothy J.
论文数: 0 引用数: 0
h-index: 0
机构:
SAIC Frederick Inc, Membrane Struct & Funct Sect, CCR Nanobiol Program, Frederick, MD USA
SAIC Frederick Inc, Lab Prote & Analyt Technol, Frederick, MD USA SAIC Frederick Inc, Struct Glycobiol Sect, CCR Nanobiol Program, Frederick, MD USA

Qasba, Pradman K.
论文数: 0 引用数: 0
h-index: 0
机构:
SAIC Frederick Inc, Struct Glycobiol Sect, CCR Nanobiol Program, Frederick, MD USA SAIC Frederick Inc, Struct Glycobiol Sect, CCR Nanobiol Program, Frederick, MD USA
[4]
Specific and covalent labeling of a membrane protein with organic fluorochromes and quantum dots
[J].
Bonasio, Roberto
;
Carman, Christopher V.
;
Kim, Enoch
;
Sage, Peter T.
;
Love, Kerry R.
;
Mempel, Thorsten R.
;
Springer, Timothy A.
;
von Andrian, Ulrich H.
.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA,
2007, 104 (37)
:14753-14758

Bonasio, Roberto
论文数: 0 引用数: 0
h-index: 0
机构: CBR Inst Biomed Res Inc, Dept Pathol, Boston, MA 02215 USA

Carman, Christopher V.
论文数: 0 引用数: 0
h-index: 0
机构: CBR Inst Biomed Res Inc, Dept Pathol, Boston, MA 02215 USA

Kim, Enoch
论文数: 0 引用数: 0
h-index: 0
机构: CBR Inst Biomed Res Inc, Dept Pathol, Boston, MA 02215 USA

Sage, Peter T.
论文数: 0 引用数: 0
h-index: 0
机构: CBR Inst Biomed Res Inc, Dept Pathol, Boston, MA 02215 USA

Love, Kerry R.
论文数: 0 引用数: 0
h-index: 0
机构: CBR Inst Biomed Res Inc, Dept Pathol, Boston, MA 02215 USA

Mempel, Thorsten R.
论文数: 0 引用数: 0
h-index: 0
机构: CBR Inst Biomed Res Inc, Dept Pathol, Boston, MA 02215 USA

Springer, Timothy A.
论文数: 0 引用数: 0
h-index: 0
机构: CBR Inst Biomed Res Inc, Dept Pathol, Boston, MA 02215 USA

von Andrian, Ulrich H.
论文数: 0 引用数: 0
h-index: 0
机构:
CBR Inst Biomed Res Inc, Dept Pathol, Boston, MA 02215 USA CBR Inst Biomed Res Inc, Dept Pathol, Boston, MA 02215 USA
[5]
Introducing genetically encoded aldehydes into proteins
[J].
Carrico, Isaac S.
;
Carlson, Brian L.
;
Bertozzi, Carolyn R.
.
NATURE CHEMICAL BIOLOGY,
2007, 3 (06)
:321-322

Carrico, Isaac S.
论文数: 0 引用数: 0
h-index: 0
机构: Univ Calif Berkeley, Dept Chem, Howard Hughes Med Inst, Berkeley, CA 94720 USA

Carlson, Brian L.
论文数: 0 引用数: 0
h-index: 0
机构: Univ Calif Berkeley, Dept Chem, Howard Hughes Med Inst, Berkeley, CA 94720 USA

Bertozzi, Carolyn R.
论文数: 0 引用数: 0
h-index: 0
机构: Univ Calif Berkeley, Dept Chem, Howard Hughes Med Inst, Berkeley, CA 94720 USA
[6]
Site-specific labeling of cell surface proteins with biophysical probes using biotin ligase
[J].
Chen, I
;
Howarth, M
;
Lin, WY
;
Ting, AY
.
NATURE METHODS,
2005, 2 (02)
:99-104

Chen, I
论文数: 0 引用数: 0
h-index: 0
机构:
MIT, Dept Chem, Cambridge, MA 02139 USA MIT, Dept Chem, Cambridge, MA 02139 USA

Howarth, M
论文数: 0 引用数: 0
h-index: 0
机构:
MIT, Dept Chem, Cambridge, MA 02139 USA MIT, Dept Chem, Cambridge, MA 02139 USA

Lin, WY
论文数: 0 引用数: 0
h-index: 0
机构:
MIT, Dept Chem, Cambridge, MA 02139 USA MIT, Dept Chem, Cambridge, MA 02139 USA

Ting, AY
论文数: 0 引用数: 0
h-index: 0
机构:
MIT, Dept Chem, Cambridge, MA 02139 USA MIT, Dept Chem, Cambridge, MA 02139 USA
[7]
GlycoPEGylation of recombinant therapeutic proteins produced in Escherichia coli
[J].
DeFrees, Shawn
;
Wang, Zhi-Guang
;
Xing, Ruye
;
Scott, Arthur E.
;
Wang, Jin
;
Zopf, David
;
Gouty, Dominique L.
;
Sjoberg, Eric R.
;
Panneerselvam, Krishnasamy
;
Brinkman-Van der Linden, Els C. M.
;
Bayer, Robert J.
;
Tarp, Mads A.
;
Clausen, Henrik
.
GLYCOBIOLOGY,
2006, 16 (09)
:833-843

DeFrees, Shawn
论文数: 0 引用数: 0
h-index: 0
机构: Neose Technol Inc, Horsham, PA 19044 USA

Wang, Zhi-Guang
论文数: 0 引用数: 0
h-index: 0
机构: Neose Technol Inc, Horsham, PA 19044 USA

Xing, Ruye
论文数: 0 引用数: 0
h-index: 0
机构: Neose Technol Inc, Horsham, PA 19044 USA

Scott, Arthur E.
论文数: 0 引用数: 0
h-index: 0
机构: Neose Technol Inc, Horsham, PA 19044 USA

Wang, Jin
论文数: 0 引用数: 0
h-index: 0
机构: Neose Technol Inc, Horsham, PA 19044 USA

Zopf, David
论文数: 0 引用数: 0
h-index: 0
机构: Neose Technol Inc, Horsham, PA 19044 USA

Gouty, Dominique L.
论文数: 0 引用数: 0
h-index: 0
机构: Neose Technol Inc, Horsham, PA 19044 USA

Sjoberg, Eric R.
论文数: 0 引用数: 0
h-index: 0
机构: Neose Technol Inc, Horsham, PA 19044 USA

Panneerselvam, Krishnasamy
论文数: 0 引用数: 0
h-index: 0
机构: Neose Technol Inc, Horsham, PA 19044 USA

Brinkman-Van der Linden, Els C. M.
论文数: 0 引用数: 0
h-index: 0
机构: Neose Technol Inc, Horsham, PA 19044 USA

Bayer, Robert J.
论文数: 0 引用数: 0
h-index: 0
机构: Neose Technol Inc, Horsham, PA 19044 USA

Tarp, Mads A.
论文数: 0 引用数: 0
h-index: 0
机构: Neose Technol Inc, Horsham, PA 19044 USA

Clausen, Henrik
论文数: 0 引用数: 0
h-index: 0
机构: Neose Technol Inc, Horsham, PA 19044 USA
[8]
Redirecting lipoic acid ligase for cell surface protein labeling with small-molecule probes
[J].
Fernandez-Suarez, Marta
;
Baruah, Hemanta
;
Martinez-Hernandez, Laura
;
Xie, Kathleen T.
;
Baskin, Jeremy M.
;
Bertozzi, Carolyn R.
;
Ting, Alice Y.
.
NATURE BIOTECHNOLOGY,
2007, 25 (12)
:1483-1487

Fernandez-Suarez, Marta
论文数: 0 引用数: 0
h-index: 0
机构: MIT, Dept Chem, Cambridge, MA 02139 USA

Baruah, Hemanta
论文数: 0 引用数: 0
h-index: 0
机构: MIT, Dept Chem, Cambridge, MA 02139 USA

Martinez-Hernandez, Laura
论文数: 0 引用数: 0
h-index: 0
机构: MIT, Dept Chem, Cambridge, MA 02139 USA

Xie, Kathleen T.
论文数: 0 引用数: 0
h-index: 0
机构: MIT, Dept Chem, Cambridge, MA 02139 USA

Baskin, Jeremy M.
论文数: 0 引用数: 0
h-index: 0
机构: MIT, Dept Chem, Cambridge, MA 02139 USA

Bertozzi, Carolyn R.
论文数: 0 引用数: 0
h-index: 0
机构: MIT, Dept Chem, Cambridge, MA 02139 USA

Ting, Alice Y.
论文数: 0 引用数: 0
h-index: 0
机构: MIT, Dept Chem, Cambridge, MA 02139 USA
[9]
Site-specific modification and PEGylation of pharmaceutical proteins mediated by transglutaminase
[J].
Fontana, Angelo
;
Spolaore, Barbara
;
Mero, Anna
;
Veronese, Francesco M.
.
ADVANCED DRUG DELIVERY REVIEWS,
2008, 60 (01)
:13-28

Fontana, Angelo
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Padua, CRIBI, Ctr Biotechnol, I-35121 Padua, Italy Univ Padua, CRIBI, Ctr Biotechnol, I-35121 Padua, Italy

Spolaore, Barbara
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Padua, CRIBI, Ctr Biotechnol, I-35121 Padua, Italy Univ Padua, CRIBI, Ctr Biotechnol, I-35121 Padua, Italy

Mero, Anna
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Padua, Dept Pharmaceut Sci, I-35131 Padua, Italy Univ Padua, CRIBI, Ctr Biotechnol, I-35121 Padua, Italy

Veronese, Francesco M.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Padua, Dept Pharmaceut Sci, I-35131 Padua, Italy Univ Padua, CRIBI, Ctr Biotechnol, I-35121 Padua, Italy
[10]
Glycoprotein Synthesis: An Update
[J].
Gamblin, David P.
;
Scanlan, Eoin M.
;
Davis, Benjamin G.
.
CHEMICAL REVIEWS,
2009, 109 (01)
:131-163

Gamblin, David P.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Oxford, Dept Chem, Chem Res Lab, Oxford OX1 3TA, England Univ Oxford, Dept Chem, Chem Res Lab, Oxford OX1 3TA, England

Scanlan, Eoin M.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Oxford, Dept Chem, Chem Res Lab, Oxford OX1 3TA, England Univ Oxford, Dept Chem, Chem Res Lab, Oxford OX1 3TA, England

Davis, Benjamin G.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Oxford, Dept Chem, Chem Res Lab, Oxford OX1 3TA, England Univ Oxford, Dept Chem, Chem Res Lab, Oxford OX1 3TA, England