Association between cyclo-oxygenase-2 overexpression and missense p53 mutations in gastric cancer

被引：102
作者：
Leung, WK [1 ]
To, KF
Ng, YP
Lee, TL
Lau, JYW
Chan, FKL
Ng, EKW
Chung, SCS
Sung, J
机构：
[1] Chinese Univ Hong Kong, Prince Wales Hosp, Dept Med & Therapeut, Shatin, Hong Kong, Peoples R China
[2] Chinese Univ Hong Kong, Prince Wales Hosp, Dept Anat & Cellular Pathol, Shatin, Hong Kong, Peoples R China
[3] Chinese Univ Hong Kong, Prince Wales Hosp, Dept Surg, Shatin, Hong Kong, Peoples R China
来源：
BRITISH JOURNAL OF CANCER | 2001年 / 84卷 / 03期
关键词：
cyclo-oxygenase-2; p53; gene; mutation; gastric cancer;
D O I：
10.1054/bjoc.2000.1607
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Wild-type p53 competitively binds to the promoter region of COX-2 in vitro and inhibits its transcription. We examined the association between p53 mutation and COX-2 expression in gastric cancer. COX-2 over-expression was seen in 19 (48.7%) cases. These tumours had more lymph-node metastasis (P = 0.048) and tended to have a poorer survival (P = 0.07). Missense mutations of p53 were detected in 20 (51.3%) patients and had a significantly stronger COX-2 expression than tumours without p53 mutation (P = 0.016). Our results suggest a link between p53 mutation and COX-2 overexpression in gastric cancer. (C) 2001 Cancer Research Campaign.
引用
收藏
页码：335 / 339
页数：5
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