Soluble HLA-G and TGF-β in couples attending assisted reproduction - A possible role of TGF-β isoforms in semen?

被引：10

作者：

Nilsson, Line Lynge ^{[1
,2
]}

Hornstrup, Micha B. ^{[3
]}

Perin, Trine L. ^{[3
]}

Lindhard, Anette ^{[3
]}

Funck, Tina ^{[1
]}

Bjerrum, Poul J. ^{[4
]}

Mule, Henriette Theilmann ^{[5
]}

Scheike, Thomas ^{[6
]}

Nielsen, Henriette Svarre ^{[2
,7
]}

Hviid, Thomas Vauvert F. ^{[1
,2
]}

机构：

[1] Zealand Univ Hosp, CIRRI, Dept Clin Biochem, ReproHlth Res Consortium ZUH, Roskilde, Denmark

[2] Univ Copenhagen, Fac Hlth & Med Sci, Dept Clin Med, Copenhagen, Denmark

[3] Zealand Univ Hosp, Dept Obstet & Gynecol, ReproHlth Res Consortium ZUH, Fertil Clin, Roskilde, Denmark

[4] Holbaek Cent Hosp, Dept Clin Biochem, Holbaek, Region Zealand, Denmark

[5] Cryos Int Aps, Aarhus, Denmark

[6] Univ Copenhagen, Dept Publ Hlth, Sect Biostat, Copenhagen, Denmark

[7] Rigshosp, Fertil Clin, Copenhagen, Denmark

来源：

JOURNAL OF REPRODUCTIVE IMMUNOLOGY | 2020年 / 137卷

关键词：

Infertility; ART; Reproduction; HLA-G; TGF-beta; LEUKOCYTE ANTIGEN-G; G MESSENGER-RNA; GROWTH-FACTOR-BETA; SEMINAL PLASMA; G GENE; EXPRESSION; PREGNANCY; POLYMORPHISM; TOLERANCE;

D O I：

10.1016/j.jri.2019.102857

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Soluble isoforms of the non-classical Human Leukocyte Antigen (HLA)-G as well as Transforming Growth Factor (TGF)-beta is expressed in seminal plasma possibly influencing the pregnancy potential. We wanted to examine the association of seminal plasma sHLA-G, TGF-beta 1, TGF-beta 2 and TGF beta 3 with pregnancy success in a cohort of 127 couples and 4 single women attending fertility treatment with the use of assisted reproduction technologies (ART). Soluble HLA-G, TGF-beta 1, TGF-beta 2 and TGF-beta 3 in seminal plasma did not fluctuate significantly over time. We did not find any impact of seminal plasma sHLA-G, TGF-beta 1, TGF-beta 2 and TGF-beta 3 on time-to-pregnancy measured as number of treatment cycles. There was a significant association between concentrations of seminal plasma sHLA-G and HLA-G variations in the 3'untranslated region (3'UTR) of the HLA-G gene, supporting and extending previous findings. Furthermore, by comparing seminal plasma concentrations of sHLA-G, TGF-beta 1, TGF-beta 2 and TGF-beta 3 in male subjects with reduced semen quality, male subjects with normal semen quality, and sperm donors, we found that TGF-beta 2 was significantly lower, and TGF-beta 3 was significantly higher, in seminal plasma from sperm donors. These findings suggest that TGF-beta isoforms may influence semen quality and fertility.

引用

页数：10

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