Generally trained models to predict solubility of drugs in carbitol plus water mixtures at various temperatures

被引：44

作者：

Khoubnasabjafari, Mehry ^{[1
]}

Shayanfar, Ali ^{[2
,3
]}

Martinez, Fleming ^{[4
]}

Acree, William E., Jr. ^{[5
]}

Jouyban, Abolghasem ^{[3
,6
,7
]}

机构：

[1] Tabriz Univ Med Sci, TB & Lung Dis Res Ctr, Tabriz, Iran

[2] Tabriz Univ Med Sci, Drug Appl Res Ctr, Tabriz 51664, Iran

[3] Tabriz Univ Med Sci, Fac Pharm, Tabriz 51664, Iran

[4] Univ Nacl Colombia, Fac Ciencias, Dept Farm, Grp Invest Farmaceut Fis Quim, Cra 30 45-03, Bogota, DC, Colombia

[5] Univ N Texas, Dept Chem, Denton, TX 76203 USA

[6] Tabriz Univ Med Sci, Pharmaceut Anal Res Ctr, Tabriz 51664, Iran

[7] Tabriz Univ Med Sci, Kimia Idea Pardaz Azarbayjan KIPA Sci Based Co, Tabriz 51664, Iran

来源：

JOURNAL OF MOLECULAR LIQUIDS | 2016年 / 219卷

关键词：

Solubility prediction; Abraham solvation parameters; Yalkowsky model; Jouyban-Acree model; Carbitol plus water; MIXED-SOLVENT SYSTEMS; COSOLVENT MIXTURES; 333.15; K; THERMODYNAMICS;

D O I：

10.1016/j.molliq.2016.03.043

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

The trained versions of Jouyban-Acree and Yalkowsky models are proposed employing solubility data sets of 11 drugs in carbitol + water mixtures at various temperatures. Using these models, the solubility of a drug in the mono-solvents, the Abraham solvation parameters and log P value of the drug, its solubility in the binary solvent mixtures at various temperatures could be predicted. The mean percentage deviations for the correlated data were 137 and 20% respectively for the Yalkowsky and Jouyban-Acree models. (C) 2016 Elsevier B.V. All rights reserved.

引用

页码：435 / 438

页数：4

共 30 条

[1] MATHEMATICAL REPRESENTATION OF THERMODYNAMIC PROPERTIES .2. DERIVATION OF THE COMBINED NEARLY IDEAL BINARY SOLVENT (NIBS) REDLICH-KISTER MATHEMATICAL REPRESENTATION FROM A 2-BODY AND 3-BODY INTERACTIONAL MIXING MODEL [J].

ACREE, WE .

THERMOCHIMICA ACTA, 1992, 198 (01) :71-79

[2]

[Anonymous], 1981, TECHNIQUES SOLUBILIZ

[3]

Budavari S., 2001, The Merck Index, An Encyclopedia of Chemicals, Drugs, and Biologicals, V13th

[4]

Connors K A., 2002, Thermodynamics of pharmaceutial systems: An introduction for students of pharmacy

[5] Solubility of Gliclazide in Transcutol plus Water Co-solvent Mixtures at (298.15 to 333.15) K [J].

Haq, Nazrul ;

Alanazi, Fars K. ;

Alsarra, Ibrahim A. ;

Shakeel, Faiyaz .

CROATICA CHEMICA ACTA, 2014, 87 (03) :255-260

[6] Review of the cosolvency models for predicting solubility of drugs in water-cosolvent mixtures [J].

Jouyban, Abolghasem .

JOURNAL OF PHARMACY AND PHARMACEUTICAL SCIENCES, 2008, 11 (01) :32-57

[7] Comparison of models for describing multiple peaks in solubility profiles [J].

Jouyban-Gharamaleki, A ;

Acree, WE .

INTERNATIONAL JOURNAL OF PHARMACEUTICS, 1998, 167 (1-2) :177-182

[8] Comparison of various cosolvency models for calculating solute solubility in water-cosolvent mixtures [J].

Jouyban-Gharamaleki, A ;

Valaee, L ;

Barzegar-Jalali, M ;

Clark, BJ ;

Acree, WE .

INTERNATIONAL JOURNAL OF PHARMACEUTICS, 1999, 177 (01) :93-101

[9] A novel method for improvement of predictability of the CNIBS/R-K equation [J].

JouybanGharamaleki, A ;

Hanaee, J .

INTERNATIONAL JOURNAL OF PHARMACEUTICS, 1997, 154 (02) :245-247

[10] Prediction of drug solubility in ethanol-ethyl acetate mixtures at various temperatures using the Jouyban-Acree model [J].

Jouybanl, A. ;

Acree, W. E., Jr. .

JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY, 2007, 17 (02) :159-160

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