Genetic variation and forensic characteristic analysis of 25 STRs of a novel fluorescence co-amplification system in Chinese Southern Shaanxi Han population

被引：5

作者：

Liu, Yao-Shun ^{[1
,2
,3
,4
]}

Chen, Jian-Gang ^{[1
,6
]}

Mei, Ting ^{[1
,2
,3
]}

Guo, Yu-Xin ^{[2
,3
]}

Meng, Hao-Tian ^{[2
,3
]}

Li, Jian-Fei ^{[5
]}

Wei, Yuan-Yuan ^{[2
,3
]}

Jin, Xiao-Ye ^{[2
,3
]}

Zhu, Bo-Feng ^{[2
,3
,4
]}

Zhang, Li-Ping ^{[1
]}

机构：

[1] Xinjiang Med Univ, Basic Med Coll, Dept Biochem & Mol Biol, Urumqi 830011, Xinjiang, Peoples R China

[2] Xi An Jiao Tong Univ, Coll Stomatol, Key Lab Shaanxi Prov Craniofacial Precis Med Res, Xian 710004, Shaanxi, Peoples R China

[3] Xi An Jiao Tong Univ, Coll Stomatol, Clin Res Ctr Shaanxi Prov Dent & Maxillofacial Di, Xian 710004, Shaanxi, Peoples R China

[4] Southern Med Univ, Sch Forens Med, Dept Forens Genet, Guangzhou 510515, Guangdong, Peoples R China

[5] Xi An Jiao Tong Univ, Sch Marxism, Xian 710049, Shaanxi, Peoples R China

[6] Xinjiang Publ Secur Dept, Sci & Technol Inst, Urumqi 830006, Xinjiang, Peoples R China

来源：

ONCOTARGET | 2017年 / 8卷 / 33期

基金：

中国国家自然科学基金;

关键词：

genetic polymorphisms; Southern Shaanxi Han population; forensic characteristic analysis; autosomal STR; Y-STR; ETHNIC-MINORITY GROUP; ALLELE FREQUENCIES; NORTHEAST CHINA; Y-CHROMOSOME; VOJVODINA PROVINCE; KOREAN POPULATION; LIAONING PROVINCE; QINGHAI PROVINCE; HUI POPULATION; JILIN PROVINCE;

D O I：

10.18632/oncotarget.19317

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

We analyzed the genetic polymorphisms of 15 autosomal and 10 Y-chromosomal STR loci in 214 individuals of Han population from Southern Shaanxi of China and studied the genetic relationships between Southern Shaanxi Han and other populations. We observed a total of 150 alleles at 15 autosomal STR loci with the corresponding allelic frequencies ranging from 0.0023 to 0.5210, and the combined power of discrimination and exclusion for the 15 autosomal STR loci were 0.99999999999999998866 and 0.999998491, respectively. For the 10 Y-STR loci, totally 100 different haplotypes were obtained, of which 94 were unique. The discriminatory capacity and haplotype diversity values of the 10 Y-STR loci were 0.9259 and 0.998269, respectively. The results demonstrated high genetic diversities of the 25 STR loci in the population for forensic applications. We constructed neighbor-joining tree and conducted principal component analysis based on 15 autosomal STR loci and conducted multidimensional scaling analysis and constructed neighbor-joining tree based on 10 Y-STR loci. The results of population genetic analyses based on both autosomal and Y-chromosome STRs indicated that the studied Southern Shaanxi Han population had relatively closer genetic relationship with Eastern Han population, and distant relationships with Croatian, Serbian and Moroccan populations.

引用

页码：55443 / 55452

页数：10