Click Chelators - The Behavior of Platinum and Palladium Complexes in the Presence of Guanosine and DNA

被引：19

作者：

Chevry, Aurelien ^{[2
]}

Teyssot, Marie-Laure ^{[2
]}

Maisonial, Aurelie ^{[2
]}

Lemoine, Pascale ^{[1
]}

Viossat, Bernard ^{[1
]}

Traikia, Mounir ^{[2
]}

Aitken, David J. ^{[2
]}

Alves, Georges ^{[3
]}

Morel, Laurent ^{[3
]}

Nauton, Lionel ^{[2
]}

Gautier, Arnaud ^{[2
]}

机构：

[1] Univ Paris 05, CNRS, Fac Pharm Lab Cristallog & RMN Biol, UMR 8015, F-75270 Paris 06, France

[2] Univ Blaise Pascal, Clermont Univ, CNRS, SEESIB,UMR 6504, F-63177 Aubiere, France

[3] Univ Blaise Pascal, Clermont Univ, CNRS, INSERM,GReD UMR 6247, F-63177 Aubiere, France

来源：

EUROPEAN JOURNAL OF INORGANIC CHEMISTRY | 2010年 / 22期

关键词：

Platinum; Palladium; Click chemistry; Conformation analysis; DNA; Antitumor agents; CONFORMATIONAL-ANALYSIS; SUGAR RING; TO-CHELATE; NUCLEOSIDES; ANTICANCER; CHEMISTRY; CYCLOADDITIONS; BIOMOLECULES; NUCLEOTIDES; DINUCLEAR;

D O I：

10.1002/ejic.201000183

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

Triazole chelators, synthesized by click chemistry, are convenient ligands for palladium(II) and platinum(II). Conformational changes induced by the complexation of these Pd-II and Pt-II complexes with guanosine are similar to those of cisplatin. In addition, these complexes behave like cisplatin with regard to the relaxation of supercoiled plasmid DNA.

引用

页码：3513 / 3519

页数：7

共 44 条

[1] ALTOMARE A, 1994, J APPL CRYSTALLOGR, V27, P27
[2] CONFORMATIONAL-ANALYSIS OF SUGAR RING IN NUCLEOSIDES AND NUCLEOTIDES - NEW DESCRIPTION USING CONCEPT OF PSEUDOROTATION
ALTONA, C
SUNDARALINGAM, M
[J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1972, 94 (23) : 8205 - +
[3] CONFORMATIONAL-ANALYSIS OF SUGAR RING IN NUCLEOSIDES AND NUCLEOTIDES - IMPROVED METHOD FOR INTERPRETATION OF PROTON MAGNETIC-RESONANCE COUPLING-CONSTANTS
ALTONA, C
SUNDARALINGAM, M
[J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1973, 95 (07) : 2333 - 2344
[4] ALTONA C, 1982, RECL TRAV CHIM PAY B, V101, P413
[5] Ammalahti E, 1996, J MAGN RESON SER A, V122, P230, DOI 10.1006/jmra.1996.0199
[6] AMTMANN E, 2004, Patent No. 018043
[7] [Anonymous], CRYSALIS RED
[8] PRACTICAL ASPECTS OF TWO-DIMENSIONAL TRANSVERSE NOE SPECTROSCOPY
BAX, A
DAVIS, DG
[J]. JOURNAL OF MAGNETIC RESONANCE, 1985, 63 (01) : 207 - 213
[9] CuI-catalyzed alkyne-azide "click" cycloadditions from a mechanistic and synthetic perspective
Bock, VD
Hiemstra, H
van Maarseveen, JH
[J]. EUROPEAN JOURNAL OF ORGANIC CHEMISTRY, 2006, 2006 (01) : 51 - 68
[10] STRUCTURE DETERMINATION OF A TETRASACCHARIDE - TRANSIENT NUCLEAR OVERHAUSER EFFECTS IN THE ROTATING FRAME
BOTHNERBY, AA
STEPHENS, RL
LEE, JM
WARREN, CD
JEANLOZ, RW
[J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1984, 106 (03) : 811 - 813

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