Classification of idiopathic inflammatory myopathies: pathology perspectives

被引:62
作者
Tanboon, Jantima [1 ]
Nishino, Ichizo [1 ,2 ,3 ]
机构
[1] NCNP, Dept Neuromuscular Res, Natl Inst Neurosci, 4-1-1 Ogawahigashi Cho, Kodaira, Tokyo 1878502, Japan
[2] NCNP, Dept Genome Med Dev, Kodaira, Tokyo, Japan
[3] NCNP, Dept Clin Genome Anal, MGC, Kodaira, Tokyo, Japan
关键词
antisynthetase syndrome; dermatomyositis; immune-mediated necrotizing myopathy; inclusion body myositis; myositis-specific antibody; INCLUSION-BODY MYOSITIS; AUTOANTIBODIES; ANTIBODY; DERMATOMYOSITIS; ADULT; NAARDEN; DISEASE; POLYMYOSITIS; DIAGNOSIS; SEVERITY;
D O I
10.1097/WCO.0000000000000740
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Purpose of review Idiopathic inflammatory myopathies (IIM) are rare diseases with heterogenous clinicopathological features. In recent years, new classification systems considering various combinations of clinical, serological, and pathological information have been proposed. This review summarizes recent clinicoseropathological development in major subgroups of IIM. Recent findings Considering clinicoseropathological features, IIM are suggestively classified into four major subgroups: dermatomyositis, immune-mediated necrotizing myopathy (IMNM), antisynthetase syndrome (ASS), and inclusion body myositis (IBM). Many historically diagnosed polymyositis have been mainly reclassified as IBM, IMNM, and ASS. Different types of myositis-specific antibodies (MSA) suggest distinct clinicopathological subsets of IIM. Excluding IBM, at least one-third of the IIMs have no known associated MSA. MSA are crucial for IIM classification but can be negative. Thus, IIM should be universally classified using stepwise or integrated information on clinical, serological, and pathological findings.
引用
收藏
页码:704 / 714
页数:11
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