The Association of ANRIL With Coronary Artery Disease And Aortic Aneurysms, How Far Does The Gene Desert Go?

被引：7
作者：
Ng, Wei Chin [1 ]
Chan, Jeremy [1 ]
Tarkas, Tillana Nirav [1 ]
Meharban, Nehman [1 ]
Munir, Wahaj [1 ]
Bashir, Mohamad [2 ]
机构：
[1] Queen Mary Univ London, Barts & London Sch Med & Dent, London, England
[2] Velindre Univ Hosp NHS Trust, Vasc & Endovasc Surg, Hlth & Educ Improvement Wales, Cardiff, Wales
来源：
ANNALS OF VASCULAR SURGERY | 2022年 / 80卷
关键词：
NONCODING RNA ANRIL; CHROMOSOME; 9P21.3; SEQUENCE VARIANT; 4; SNPS; LOCUS; RISK; POLYCOMB; SUSCEPTIBILITY; INFLAMMATION; PREVALENCE;
D O I：
10.1016/j.avsg.2021.10.031
中图分类号：
R61 [外科手术学];
学科分类号：
摘要：
Background: Coronary artery disease (CAD) and aortic aneurysms (AA) are 2 cardiovascular diseases that share a multifactorial aetiology. The influence of family history and genetics on the 2 diseases separately and in association is well known, but poorly elucidated. This comprehensive review aims to examine the current literature on the gene ANRIL (antisense non-coding RNA in the INK4 locus) and its associations with CAD and AA. Methods: A database search on OVID, PubMed and Cochrane to identify articles concerning single nucleotide polymorphisms (SNPs) associated with ANRIL and their respective incidences of, and impact on, CAD and AA across populations. Results: Cohort studies across various ethnicities reveal that various ANRIL SNPs are significantly associated separately with CAD (rs1333040, rs1333049 and rs2383207) and AA (rs564398, rs10757278 and rs1333049), and that these SNPs are present in significant proportions of the population. SNP rs1333049 is significantly associated with both diseases, but is positively correlated with AAA and negatively correlated with CAD. This review further outlines several pathophysiological links via endothelial and adventitial cells, vascular smooth muscle cells and sense gene interaction, which may explain these genetic associations identified. Conclusion: Given the associations uncovered between ANRIL polymorphisms and CAD and AA, as well as the molecular mechanisms which may explain the underlying pathophysiology, ANRIL appears to be strongly linked with both diseases. ANRIL may hence have a future application in screening normal patients and risk stratifying patients with both diseases. Its role in linking the 2 diseases is yet unclear, warranting further studies.
引用
收藏
页码：345 / 357
页数：13
相关论文
共 57 条
[1]   Four SNPS on chromosome 9p21 confer risk to premature, familial CAD and MI in an American Caucasian population (GeneQuest) [J].
Abdullah, K. G. ;
Li, L. ;
Shen, G. -Q. ;
Hu, Y. ;
Yang, Y. ;
MacKinlay, K. G. ;
Topol, E. J. ;
Wang, Q. K. .
ANNALS OF HUMAN GENETICS, 2008, 72 :654-657
[2]   Long Non-coding RNA ANRIL and Polycomb in Human Cancers and Cardiovascular Disease [J].
Aguilo, Francesca ;
Di Cecilia, Serena ;
Walsh, Martin J. .
LONG NON-CODING RNAS IN HUMAN DISEASE, 2016, 394 :29-39
[3]   Genetic variation at the 9p21 locus predicts angiographic coronary artery disease prevalence but not extent and has clinical utility [J].
Anderson, Jeffrey L. ;
Horne, Benjamin D. ;
Kolek, Matthew J. ;
Muhlestein, Joseph B. ;
Mower, Chrissa P. ;
Park, James J. ;
May, Heidi T. ;
Camp, Nicola J. ;
Carlquist, John F. .
AMERICAN HEART JOURNAL, 2008, 156 (06) :1155-1162
[4]  
[Anonymous], 2021, REC ABD AORT AN DIAG
[5]   Predictive role of circulating endothelial-derived microparticles in cardiovascular diseases [J].
Berezin, Alexander ;
Zulli, Anthony ;
Kerrigan, Steve ;
Petrovic, Daniel ;
Kruzliak, Peter .
CLINICAL BIOCHEMISTRY, 2015, 48 (09) :562-568
[6]   Association of an allele on chromosome 9 and abdominal aortic aneurysm [J].
Biros, Erik ;
Cooper, Matthew ;
Palmer, Lyle J. ;
Walker, Philip J. ;
Norman, Paul E. ;
Golledge, Jonathan .
ATHEROSCLEROSIS, 2010, 212 (02) :539-542
[7]   Long Noncoding RNAs From Clinical Genetics to Therapeutic Targets? [J].
Boon, Reinier A. ;
Jae, Nicolas ;
Holdt, Lesca ;
Dimmeler, Stefanie .
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2016, 67 (10) :1214-1226
[8]   Association Between the Coronary Artery Disease Risk Locus on Chromosome 9p21.3 and Abdominal Aortic Aneurysm [J].
Bown, Matthew J. ;
Braund, Peter S. ;
Thompson, John ;
London, Nicholas J. M. ;
Samani, Nilesh J. ;
Sayers, Robert D. .
CIRCULATION-CARDIOVASCULAR GENETICS, 2008, 1 (01) :39-42
[9]   Susceptibility to coronary artery disease and diabetes is encoded by distinct, tightly linked SNPs in the ANRIL locus on chromosome 9p [J].
Broadbent, Helen M. ;
Peden, John F. ;
Lorkowski, Stefan ;
Goel, Anuj ;
Ongen, Halit ;
Green, Fiona ;
Clarke, Robert ;
Collins, Rory ;
Franzosi, Maria Grazia ;
Tognoni, Gianni ;
Seedorf, Udo ;
Rust, Stephan ;
Eriksson, Per ;
Hamsten, Anders ;
Farrall, Martin ;
Watkins, Hugh .
HUMAN MOLECULAR GENETICS, 2008, 17 (06) :806-814
[10]   Evaluation of association between common genetic variants on chromosome 9p21 and coronary artery disease in Turkish population [J].
Cakmak, Huseyin Altug ;
Bayoglu, Burcu ;
Durmaz, Eser ;
Can, Gunay ;
Karadag, Bilgehan ;
Cengiz, Mujgan ;
Vural, Vural Ali ;
Yuksel, Husniye .
ANADOLU KARDIYOLOJI DERGISI-THE ANATOLIAN JOURNAL OF CARDIOLOGY, 2015, 15 (03) :196-203
123456