Salvianolic Acid Y: A New Protector of PC12 Cells against Hydrogen Peroxide-Induced Injury from Salvia officinalis

被引：25

作者：

Gong, Jun ^{[1
]}

Ju, Aichun ^{[1
]}

Zhou, Dazheng ^{[1
]}

Li, Dekun ^{[1
]}

Zhou, Wei ^{[2
]}

Geng, Wanli ^{[2
]}

Li, Bing ^{[1
]}

Li, Li ^{[1
]}

Liu, Yanjie ^{[1
]}

He, Ying ^{[1
]}

Song, Meizhen ^{[1
]}

Wang, Yunhua ^{[1
]}

Ye, Zhengliang ^{[1
]}

Lin, Ruichao ^{[3
]}

机构：

[1] TianJin Tasly Pride Pharmaceut Co Ltd, Dev Technol Dept, Tianjin 300410, Peoples R China

[2] Tasly Pharmaceut Co Ltd, Tasly R&D Inst, Tianjin 300410, Peoples R China

[3] Beijing Univ Chinese Med, Sch Chinese Mat Med, Beijing 100050, Peoples R China

来源：

MOLECULES | 2015年 / 20卷 / 01期

关键词：

PC12; cells; Salvia officinalis; circular dichroism (CD); DERIVATIVES; HUPERZINE;

D O I：

10.3390/molecules20010683

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Salvianolic acid Y (TSL 1), a new phenolic acid with the same planar structure as salvianolic acid B, was isolated from Salvia officinalis. The structural elucidation and stereochemistry determination were achieved by spectroscopic and chemical methods, including 1D, 2D-NMR (H-1-H-1 COSY, HMQC and HMBC) and circular dichroism (CD) experiments. The biosynthesis pathway of salvianolic acid B and salvianolic acid Y (TSL 1) was proposed based on structural analysis. The protection of PC12 cells from injury induced by H2O2 was assessed in vitro using a cell viability assay. Salvianolic acid Y (TSL 1) protected cells from injury by 54.2%, which was significantly higher than salvianolic acid B (35.2%).

引用

页码：683 / 692

页数：10

共 23 条

[1] STEREOSTRUCTURE OF SALVIANOLIC ACID-B AND ISOLATION OF SALVIANOLIC ACID-C FROM SALVIA-MILTIORRHIZA
AI, CB
LI, LN
[J]. JOURNAL OF NATURAL PRODUCTS, 1988, 51 (01): : 145 - 149
[2] Application of electronic circular dichroism in configurational and conformational analysis of organic compounds
Berova, Nina
Di Bari, Lorenzo
Pescitelli, Gennaro
[J]. CHEMICAL SOCIETY REVIEWS, 2007, 36 (06) : 914 - 931
[3] STRUCTURE ELUCIDATION AND TOTAL SYNTHESIS OF NEW TANSHINONES ISOLATED FROM SALVIA-MILTIORRHIZA BUNGE (DANSHEN)
CHANG, HM
CHENG, KP
CHOANG, TF
CHOW, HF
CHUI, KY
HON, PM
TAN, FWL
YANG, Y
ZHONG, ZP
LEE, CM
SHAM, HL
CHAN, CF
CUI, YX
WONG, HNC
[J]. JOURNAL OF ORGANIC CHEMISTRY, 1990, 55 (11) : 3537 - 3543
[4] Chen Z.X., 1981, CHINESE PHARMACOL B, V15, P24
[5] Salvianolic acid B inhibits the amyloid formation of human islet amyloid polypeptideand protects pancreatic beta-cells against cytotoxicity
Cheng, Biao
Gong, Hao
Li, Xiaochao
Sun, Yue
Chen, Hong
Zhang, Xin
Wu, Qian
Zheng, Ling
Huang, Kun
[J]. PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS, 2013, 81 (04) : 613 - 621
[6] Chemistry and biological activities of caffeic acid derivatives from Salvia miltiorrhiza
Jiang, RW
Lau, KM
Hon, PM
Mak, TCW
Woo, KS
Fung, KP
[J]. CURRENT MEDICINAL CHEMISTRY, 2005, 12 (02) : 237 - 246
[7] Beyond Polymaxenolide: Cembrane-Africanane Terpenoids from the Hybrid Soft Coral Sinularia maxima x S. polydactyla
Kamel, Haidy N.
Ding, Yuanqing
Li, Xing-Cong
Ferreira, Daneel
Fronczek, Frank R.
Slattery, Marc
[J]. JOURNAL OF NATURAL PRODUCTS, 2009, 72 (05): : 900 - 905
[8] Li L.-N., 1997, J. Chinese Pharmacetical Sci, V6, P57
[9] A polysaccharide isolated from Cordyceps sinensis, a traditional Chinese medicine, protects PC12 cells against hydrogen peroxide-induced injury
Li, SP
Zhao, KJ
Ji, ZN
Song, ZH
Dong, TTX
Lo, CK
Cheung, JKH
Zhu, SQ
Tsim, KWK
[J]. LIFE SCIENCES, 2003, 73 (19) : 2503 - 2513
[10] LIU J, 2012, CHIN J EXP TRAD MED, V18, P288

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