Retrieval improvement is induced by water shortage through angiotensin II

被引:22
作者
Frenkel, L [1 ]
Maldonado, H [1 ]
Delorenzi, A [1 ]
机构
[1] Univ Buenos Aires, CONICET, IFIBYNE,Dept Fisiol & Biol Mol & Celular, Fac Ciencias Exactas & Nat,Lab Neurobiol Memoria, Buenos Aires, DF, Argentina
关键词
angiotensin; crustacea; invertebrate; neuropeptide; memory; retrieval; osmoregulation;
D O I
10.1016/j.nlm.2004.11.001
中图分类号
B84 [心理学]; C [社会科学总论]; Q98 [人类学];
学科分类号
03 ; 0303 ; 030303 ; 04 ; 0402 ;
摘要
Angiotensin 11 (ANGII) has an evolutionary preserved role in determining adaptative responses to water-shortages. In addition, it has been shown to modulate diverse phases of memory. Still, it is not clear whether ANGII improves or spoils memory. We demonstrated that endogenous angiotensins enhance consolidation of a long-term associative memory in the crab Chasmagnathus and that water shortage improves memory consolidation through brain ANGII actions. Here, we show that weakly trained crabs, when water-deprived, exhibit enhanced retrieval. Subsequently, memory retention is indistinguishable from that of strongly trained crabs. ANGII, but not angiotensin IV, is a necessary and sufficient condition for such enhancing effect. We conclude that ANGII released due to water shortage leads to enhanced memory retrieval. Thus, it seems that ANGII has an evolutionary preserved role as a multi-function coordinator that enables an adaptative response to water-shortage. The facilitation of memory consolidation and retrieval would be among those coordinated functions. (C) 2004 Elsevier Inc. All rights reserved.
引用
收藏
页码:173 / 177
页数:5
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