Quantitative two-dimensional photoacoustic tomography of osteoarthritis in the finger joints

被引：42

作者：

Xiao, Jiaying ^{[1
,2
]}

Yao, Lei ^{[2
]}

Sun, Yao ^{[2
]}

Sobel, Eric S. ^{[3
]}

He, Jishan ^{[1
]}

Jiang, Huabei ^{[2
]}

机构：

[1] Cent S Univ, Inst Biomed Engn, Sch Infophys Geomat Engn, Changsha 410083, Peoples R China

[2] Univ Florida, J Crayton Pruitt Family Dept Biomed Engn, Gainesville, FL 32611 USA

[3] Univ Florida, Coll Med, Div Rheumatol, Gainesville, FL 32611 USA

来源：

OPTICS EXPRESS | 2010年 / 18卷 / 14期

关键词：

OPTICAL-ABSORPTION COEFFICIENT; ARTICULAR-CARTILAGE; TURBID MEDIA; RHEUMATOID-ARTHRITIS; RECONSTRUCTION; HEMODYNAMICS; THICKNESS; EQUATION; DEFECTS; TISSUES;

D O I：

10.1364/OE.18.014359

中图分类号：

O43 [光学];

学科分类号：

070207 ; 0803 ;

摘要：

We present for the first time in vivo experimental evidence that quantitative photoacoustic tomography (qPAT) has the potential to detect osteoarthritis (OA) in the finger joints. In this pilot study, 2 OA patients and 4 healthy volunteers were enrolled, and their distal interphalangeal (DIP) joints were examined photoacoustically by a PAT scanner. Tissue absorption coefficient images of all the examined joints, which were unavailable from the conventional PAT, were recovered using our finite element based qPAT approach. The recovered quantitative photoacoustic images revealed significant differences in the tissue absorption coefficient of the joint cavity (cartilage and synovial fluid) between the OA and normal joints. (C) 2010 Optical Society of America

引用

页码：14359 / 14365

页数：7

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