Neurosteroid vitamin D system as a nontraditional drug target in neuropsychopharmacology

被引：30
作者：
Stewart, Adam [1 ]
Wong, Keith [1 ]
Cachat, Jonathan [1 ]
Elegante, Marco [1 ]
Gilder, Tom [1 ]
Mohnot, Sopan [1 ]
Wu, Nadine [1 ]
Minasyan, Anna [2 ]
Tuohimaa, Pentti [2 ]
Kalueff, Allan V. [1 ]
机构：
[1] Tulane Univ, Sch Med, Dept Pharmacol & Neurosci, New Orleans, LA 70112 USA
[2] Tampere Univ, Sch Med, Dept Anat, FIN-33101 Tampere, Finland
来源：
BEHAVIOURAL PHARMACOLOGY | 2010年 / 21卷 / 5-6期
关键词：
genetic polymorphisms; hypovitaminosis D; mutant mouse models; neurobehavioral disorders; vitamin D; vitamin D receptor; D DEFICIENCY ALTERS; WORSE COGNITIVE PERFORMANCE; CHEMICALLY-INDUCED SEIZURES; D-RECEPTOR; ADULT-RAT; D SUPPLEMENTATION; MICE LACKING; 1,25-DIHYDROXYVITAMIN D-3; DEPRESSIVE SYMPTOMS; PARATHYROID-HORMONE;
D O I：
10.1097/FBP.0b013e32833c850f
中图分类号：
B84 [心理学]; C [社会科学总论]; Q98 [人类学];
学科分类号：
03 ; 0303 ; 030303 ; 04 ; 0402 ;
摘要：
Vitamin D is becoming increasingly recognized as a nontraditional drug target for different brain pathologies. Although widely known for their role in calcium metabolism, vitamin D and its receptor have been linked to several brain disorders, including cognitive decline, epilepsy, affective disorders, and schizophrenia. Here we discuss mounting evidence, and parallel recent clinical and animal behavioral, genetic and pharmacological data to emphasize the emerging role of the neurosteroid vitamin D system in brain function. Behavioural Pharmacology 21:420-426 (C) 2010 Wolters Kluwer Health vertical bar Lippincott Williams & Wilkins.
引用
收藏
页码：420 / 426
页数：7
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