25S rDNA genotype and antifungal susceptibility of clinical Candida albicans in Ouagadougou (Burkina Faso)

被引：3

作者：

Zida, Adama ^{[1
,2
,3
]}

Issiaka, Soulama ^{[4
]}

Sanata, Bamba ^{[3
]}

Samuel, Serme S. ^{[4
,5
]}

Ibrahim, Sangare ^{[3
,6
]}

Marcel, Sawadogo ^{[1
,2
]}

Thierry, Guiguemde ^{[2
]}

Kady, Traore Lady ^{[2
]}

Robert, Guiguemde T. ^{[2
,3
,7
]}

机构：

[1] Ctr Hosp Univ Yalgado Ouedraogo, Serv Parasitol Mycol, 03 BP 7022 Ouaga 03, Ouagadougou, Burkina Faso

[2] Univ Ouaga I Joseph Ki Zerbo, Unite Format & Rech Sci Sante, Ouagadougou, Burkina Faso

[3] Univ Polytechn Bobo Dioulasso, Inst Super Sci Sante, Bobo Dioulasso, Burkina Faso

[4] Ctr Natl Rech & Format Paludisme, Bobo Dioulasso, Burkina Faso

[5] Ecole Privee Sant Sci Nouvelles ESSN, Bobo Dioulasso, Burkina Faso

[6] Ctr Hosp Univ Souro Sanou, Bobo Dioulasso, Burkina Faso

[7] Ctr Hosp Univ Charles De Gaulles, Ouagadougou, Burkina Faso

来源：

MEDICAL MYCOLOGY | 2018年 / 56卷 / 07期

关键词：

Candida albicans; 25S rDNA genotype; antifungal susceptibility; candidiasis; Burkina Faso; DUBLINIENSIS;

D O I：

10.1093/mmy/myx127

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

The present investigation aimed to assess the prevalence of genotypes of C. albicans in Ouagadougou and to analyze the relationship between the genetic diversity and anti-fungal susceptibility. Ninety-six clinical strains are included. They were diagnosed as C. albicans using germ tube test, chlamydospore formation, and Api-Candida test. Genotyping was performed using PCR targeting 25S rDNA. Antifungal susceptibilities were tested based on the disk diffusion method. The genotypes A (85.4%) was predominant followed by genotypes B (10.4%) and C (4.2%). The highest resistance rate with genotype A was obtained with fluconazole (74.4%). A resistance to amphotericin B was observed with genotypes A (29.3%) and B (30%).

引用

页码：907 / 910

页数：4

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