CT patterns and serial CT Changes in lung Cancer patients post stereotactic body radiotherapy (SBRT)

被引:10
作者
Al-Umairi, Rashid [1 ]
Tarique, Usman [1 ]
Moineddin, Rahim [2 ]
Jimenez-Juan, Laura [3 ]
Kha, Lan Chau [1 ]
Cheung, Patrick [4 ]
Oikonomou, Anastasia [1 ]
机构
[1] Univ Toronto, Sunnybrook Hlth Sci Ctr, Dept Med Imaging, 2075 Bayview Ave, Toronto, ON M4N3M5, Canada
[2] Univ Toronto, Dalla Lana Sch Publ Hlth, Dept Family & Community Med, 500 Univ Ave, Toronto, ON M5G 1V7, Canada
[3] Univ Toronto, Dept Med Imaging, St Michaels Hosp,30 Bond St, Toronto, ON M5B 1W8, Canada
[4] Univ Toronto, Sunnybrook Hlth Sci Ctr, Dept Radiat Oncol, 2075 Bayview Ave, Toronto, ON M4N 3M5, Canada
关键词
Computed tomography; Lung cancer; Stereotactic body radiotherapy; Radiation induced lung injury; CT patterns; RADIATION-THERAPY; ABLATIVE RADIOTHERAPY; FOLLOW-UP; INJURY; RECURRENCE; TUMORS; APPEARANCES; SABR;
D O I
10.1186/s40644-022-00491-1
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Background To evaluate computed tomography (CT) patterns of post-SBRT lung injury in lung cancer and identify time points of serial CT changes. Materials and methods One hundred eighty-three tumors in 170 patients were evaluated on sequential CTs within 29 months (median). Frequencies of post-SBRT CT patterns and time points of initiation and duration were assessed. Duration of increase of primary lesion or surrounding injury without evidence of local recurrence and time to stabilization or local recurrence were evaluated. Results Post-SBRT CT patterns could overlap in the same patient and were nodule-like pattern (69%), consolidation with ground glass opacity (GGO) (41%), modified conventional pattern (39%), peribronchial/patchy consolidation (42%), patchy GGO (24%), diffuse consolidation (16%), "orbit sign" (21%), mass-like pattern (19%), scar-like pattern (15%) and diffuse GGO (3%). Patchy GGO started at 4 months post-SBRT. Peribronchial/patchy consolidation and consolidation with GGO started at 4 and 5 months respectively. Diffuse consolidation, diffuse GGO and orbit sign started at 5, 6 and 8 months respectively. Mass-like, modified conventional and scar-like pattern started at 8, 12 and 12 months respectively. Primary lesion (n = 11) or surrounding injury (n = 85) increased up to 13 months. Primary lesion (n = 119) or surrounding injury (n = 115) started to decrease at 4 and 9 months respectively. Time to stabilization was 20 months. The most common CT pattern at stabilization was modified conventional pattern (49%), scar-like pattern (23%) and mass-like pattern (12%). Local recurrence (n = 15) occurred at a median time of 18 months. Conclusion Different CT patterns of lung injury post-SBRT appear in predictable time points and have variable but predictable duration. Familiarity with these patterns and timeframes of appearance helps differentiate them from local recurrence.
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页数:13
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