Effect of the Synadenium carinatum latex lectin (ScLL) on Leishmania (Leishmania) amazonensis infection in murine macrophages

被引：22
作者：
Afonso-Cardoso, Sandra R. [1 ]
Silva, Claudio Vieira [1 ]
Ferreira, Marcelo S. [2 ]
Souza, Maria A. [1 ]
机构：
[1] Univ Fed Uberlandia, Inst Ciencias Biomed, BR-38400902 Uberlandia, MG, Brazil
[2] Univ Fed Uberlandia, Fac Med, BR-38400902 Uberlandia, MG, Brazil
来源：
EXPERIMENTAL PARASITOLOGY | 2011年 / 128卷 / 01期
关键词：
Leishmania (Leishmania) amazonensis; Synadenium carinatum; Leishmanicidal activity; Nitric oxide; Lectin; NITRIC-OXIDE PRODUCTION; GALACTOSE-BINDING LECTIN; ANTILEISHMANIAL ACTIVITY; CUTANEOUS LEISHMANIASIS; POSSIBLE INVOLVEMENT; IN-VITRO; FLAVONOIDS; INHIBITION; RESISTANCE; EFFICACY;
D O I：
10.1016/j.exppara.2011.02.006
中图分类号：
R38 [医学寄生虫学]; Q [生物科学];
学科分类号：
07 ; 0710 ; 09 ; 100103 ;
摘要：
Antiparasitic effect of a lectin isolated from Synadenium carinatum latex (ScLL) was evaluated against Leishmania (Leishmania) amazonensis promastigotes/amastigotes. Pretreatment of murine inflammatory peritoneal macrophages with ScLL reduced by 65.5% the association index of macrophages and L. (L) amazonensis promastigotes. Expression of cytokines (IL-12, IL-1 and TNF-alpha) was detected in infected macrophages pretreated with ScLL (10 mu g/mL). ScLL also reduced the growth oft. (L) amazonensis amastigote intracellular forms, showing no in vitro cytotoxic effects in mammalian host cells. ScLL treatment in infected murine inflammatory peritoneal macrophages did not induce nitric oxide production, suggesting that a nitric oxide independent pathway is activated to decrease the number of intracellular Leishmania. (C) 2011 Elsevier Inc. All rights reserved.
引用
收藏
页码：61 / 67
页数：7
相关论文
共 50 条
  • [21] Miltefosine and amphoterin B induce membrane rigidity in Leishmania amazonensis and Leishmania-infected macrophages
    Borges, Ellyessa Nascimento
    Silva, Kleber Santiago Freitas e
    Cardoso, Eder Jeferson Souza
    Lima, Eliana Martins
    Mendanha, Sebastiao Antonio
    Alonso, Antonio
    ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, 2025, 769
  • [22] Anti-asthmatic potential of a D-galactose-binding lectin from Synadenium carinatum latex
    Rogerio, Alexandre P.
    Cardoso, Cristina R.
    Fontanari, Caroline
    Souza, Maria A.
    Afonso-Cardoso, Sandra R.
    Silva, Erika V. G.
    Koyama, Natalia S.
    Baseil, Fernanda L.
    Soares, Edson G.
    Calixto, Joao B.
    Stowell, Sean R.
    Dias-Baruffi, Marcelo
    Faccioli, Lucia H.
    GLYCOBIOLOGY, 2007, 17 (08) : 795 - 804
  • [23] The effect of phospholipase A2 from Crotalus durissus collilineatus on Leishmania (Leishmania) amazonensis infection
    Luiz Felipe Domingues Passero
    Márcia Dalastra Laurenti
    Thaise Y. Tomokane
    Carlos Eduardo P. Corbett
    Marcos H. Toyama
    Parasitology Research, 2008, 102 : 1025 - 1033
  • [24] In Vitro Modulator Effect of Total Extract from the Endophytic Paenibacillus polymyxa RNC-D in Leishmania (Leishmania) amazonensis and Macrophages
    Neris, Debora Meira
    Ortolani, Leticia Goncalves
    Castro, Cynthia Aparecida de
    Correia, Ricardo de Oliveira
    Rodolpho, Joice Margareth de Almeida
    Camillo, Luciana
    Nogueira, Camila Tita
    Sousa, Cristina Paiva de
    Anibal, Fernanda de Freitas
    INTERNATIONAL JOURNAL OF MICROBIOLOGY, 2020, 2020
  • [25] Leishmania donovani nucleoside hydrolase terminal domains in cross-protective immunotnerapy against Leishmania amazonensis murine infection
    Nico, Dirlei
    Gomes, Daniele Crespo
    Palatnik-de-Sousa, Iam
    Morrot, Alexandre
    Palatnik, Marcos
    Palatnik-de-Sousa, Clarisa Beatriz
    FRONTIERS IN IMMUNOLOGY, 2014, 5 : 1 - 12
  • [26] IL-32γ promotes the healing of murine cutaneous lesions caused by Leishmania braziliensis infection in contrast to Leishmania amazonensis
    Gomes, Rodrigo Saar
    Teodoro Silva, Muriel Vilela
    dos Santos, Jessica Cristina
    de Lima Silva, Lucas Luiz
    Batista, Aline Carvalho
    Machado, Juliana Reis
    Teixeira, Mauro Martins
    Dorta, Miriam Leandro
    Pelli de Oliveira, Milton Adriano
    Dinarello, Charles A.
    Joosten, Leo A. B.
    Ribeiro-Dias, Fatima
    PARASITES & VECTORS, 2017, 10
  • [27] IL-32γ promotes the healing of murine cutaneous lesions caused by Leishmania braziliensis infection in contrast to Leishmania amazonensis
    Rodrigo Saar Gomes
    Muriel Vilela Teodoro Silva
    Jéssica Cristina dos Santos
    Lucas Luiz de Lima Silva
    Aline Carvalho Batista
    Juliana Reis Machado
    Mauro Martins Teixeira
    Miriam Leandro Dorta
    Milton Adriano Pelli de Oliveira
    Charles A Dinarello
    Leo A. B. Joosten
    Fátima Ribeiro-Dias
    Parasites & Vectors, 10
  • [28] Comparative Proteomic Analysis of Murine Cutaneous Lesions Induced by Leishmania amazonensis or Leishmania major
    Negrao, Fernanda
    Giorgio, Selma
    Eberlin, Marcos Nogueira
    Yates, John R., III
    ACS INFECTIOUS DISEASES, 2019, 5 (08): : 1295 - 1305
  • [29] Natural canine infection by Leishmania infantum and Leishmania amazonensis and their implications for disease control
    Sanches, Leticia da Cruz
    de Martini, Cleber Costa
    Nakamura, Alex Akira
    Bodini Santiago, Maria Emilia
    de Lima, Beatriz Dolabela
    Felix de Lima, Valeria Marcal
    REVISTA BRASILEIRA DE PARASITOLOGIA VETERINARIA, 2016, 25 (04): : 465 - 469
  • [30] Antimony resistance associated with persistence of Leishmania (Leishmania) infantum infection in macrophages
    Magalhaes, Lucas Sousa
    Santos Bomfim, Lays Gisele
    Oliveira Santos, Camilla Natalia
    dos Santos, Priscila Lima
    Tanajura, Diego Moura
    Lipscomb, Michael Wheeler
    de Jesus, Amelia Ribeiro
    de Almeida, Roque Pacheco
    de Moura, Tatiana Rodrigues
    PARASITOLOGY RESEARCH, 2021, 120 (08) : 2959 - 2964
12345