Analytical and diagnostic aspects of carbohydrate deficient transferrin (CDT): A critical review over years 2007-2017

被引：44
作者：
Bortolotti, F. [1 ]
Sorio, D. [1 ]
Bertaso, A. [1 ]
Tagliaro, F. [1 ,2 ]
机构：
[1] Univ Verona, Unit Forens Med, Dept Diagnost & Publ Hlth, Verona, Italy
[2] Sechenov First Med Univ, Inst Pharm & Translat Med, Moscow, Russia
来源：
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS | 2018年 / 147卷
关键词：
Carbohydrate deficient transferrin; Biomarkers of alcohol abuse; Analytical methods; Diagnostic sensitivity; Diagnostic specificity; CAPILLARY-ZONE-ELECTROPHORESIS; HAIR ETHYL GLUCURONIDE; CHRONIC ALCOHOL-CONSUMPTION; RAD PERCENT-CDT; CONGENITAL DISORDERS; HUMAN SERUM; LIVER-DISEASE; BIOLOGICAL MARKERS; PREGNANT-WOMEN; HEAVY DRINKING;
D O I：
10.1016/j.jpba.2017.09.006
中图分类号：
O65 [分析化学];
学科分类号：
070302 ; 081704 ;
摘要：
The need for investigating alcohol abuse by means of objective tools is worldwide accepted. Among the currently available biomarkers of chronic alcohol abuse, carbohydrate-deficient transferrin (CDT) is one of the most used indicator, mainly because of its high specificity. However, some CDT analytical and interpretation aspects are still under discussion, as witnessed by numerous research papers and reviews. The present article presents a critical review of the literature on CDT appeared in the period from 2007 to 2017 (included). The article is organized in the following sections: (1) introduction, (2) pre-analytical aspects (3) analytical aspects (4) diagnostic aspects (5) concluding remarks. As many as 139 papers appeared in the international literature and retrieved by the search engines PubMed, Web of Science and Scopus are quoted. (C) 2017 Elsevier B.V. All rights reserved.
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页码：2 / 12
页数：11
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