Development and Characterization of Gallium-Doped Bioactive Glasses for Potential Bone Cancer Applications

被引：33
|
作者：
Rana, Karan S.
de Souza, Lucas Pereira
Isaacs, Mark A.
Raja, Farah N. S.
Morrell, Alexander P.
Martin, Richard A. [1 ]
机构：
[1] Univ Aston, Aston Inst Mat Res, Sch Engn & Appl Sci, Birmingham B4 7ET, W Midlands, England
来源：
ACS BIOMATERIALS SCIENCE & ENGINEERING | 2017年 / 3卷 / 12期
关键词：
bioactive glass; gallium; cancer; sarcoma; bone; apatite; PHOSPHATE-BASED GLASSES; X-RAY-DIFFRACTION; CALCIUM-PHOSPHATE; IN-VIVO; PARTICULATE BIOGLASS(R); HYDROXYAPATITE; SCAFFOLDS; DELIVERY; NITRATE; PH;
D O I：
10.1021/acsbiomaterials.7b00283
中图分类号：
TB3 [工程材料学]; R318.08 [生物材料学];
学科分类号：
0805 ; 080501 ; 080502 ;
摘要：
In this study, we have developed a series of novel gallium oxide doped bioactive glasses to specifically target osteosarcoma cells while aiding new bone formation. The results show that osteosarcoma (Saos-2) cell death is induced through the addition of gallium oxide. Relative to the gallium-free control glass (0% Ga) glasses containing 1, 2, and 3% Ga decreased Saos-2 cell viability in a dose dependent manner. After 72 h in media preconditioned with 3% Ga Saos-2 cell viability was reduced by over 50%. Corresponding studies undertaken on primary normal human osteoblast cells (NHOst) demonstrated no adverse effects to the gallium containing glasses. Hydroxyapatite formation was observed for all glasses when exposed to simulated body fluid.
引用
收藏
页码：3425 / 3432
页数：8
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