Antioxidant and hepatoprotective activities of intracellular polysaccharide from Pleurotus eryngii SI-04

被引：63
作者：
Zhang, Chen [1 ]
Li, Shangshang [1 ]
Zhang, Jianjun [1 ]
Hu, Chunlong [2 ]
Che, Gen [3 ]
Zhou, Meng [4 ]
Jia, Le [1 ]
机构：
[1] Shandong Agr Univ, Coll Life Sci, Tai An 271018, Shandong, Peoples R China
[2] Shandong Agr Univ, Coll Forestry, Tai An 271018, Shandong, Peoples R China
[3] Shandong Acad Agr Sci, Jinan 250100, Peoples R China
[4] Qual & Safety Monitoring Ctr Anim Prod, Jinan 250002, Peoples R China
来源：
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES | 2016年 / 91卷
关键词：
Intracellular polysaccharide; Pleurotus eryngii SI-04; Antioxidant and hepatoprotective activity; MYCELIA ZINC POLYSACCHARIDE; CARBON-TETRACHLORIDE; OXIDATIVE STRESS; FREE-RADICALS; HUMAN-DISEASE; IN-VITRO; FT-IR; MUSHROOM; EXTRACT; LIVER;
D O I：
10.1016/j.ijbiomac.2016.05.104
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
In present study, the intracellular polysaccharide (IPS) and its two fractions of IPS-1 and IPS-2 were obtained and purified by DEAE-52 cellulose chromatography from Pleurotus eryngii SI-04 mycelia, and their hepatoprotective effects were also investigated. The results showed that the IPS-2 had superior hepatoprotective effects by increasing the serum enzyme activities and bilirubin (BIL) levels, decreasing the serum albumin (ALB) and triglyceride (TG) levels, improving the hepatic antioxidant status, and ameliorating the hepatic structure damage. Furthermore, the monosaccharide composition and main bond types were also analyzed. These conclusions demonstrated that the both IPS and its fractions might be suitable for functional foods and natural drugs in preventing the acute liver damage. (C) 2016 Elsevier B.V. All rights reserved.
引用
收藏
页码：568 / 577
页数：10
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