Plasma level of interleukin-18 and complicated course of febrile neutropenia in hematological patients after intensive chemotherapy

被引：1

作者：

Korpelainen, Sini ^{[1
,2
]}

Hamalainen, Sari ^{[3
]}

Vanska, Matti ^{[4
]}

Koivula, Irma ^{[1
,3
]}

Pulkki, Kari ^{[5
,6
,7
]}

Jantunen, Esa ^{[1
,2
,3
]}

Juutilainen, Auni ^{[1
,3
]}

Purhonen, Anna-Kaisa ^{[1
,3
,8
]}

机构：

[1] Univ Eastern Finland, Inst Clin Med, Sch Med, Fac Hlth Sci, Kuopio, Finland

[2] Siun Sote Hosp Dist North Carelia, Joensuu, Finland

[3] Kuopio Univ Hosp, Dept Med, Kuopio, Finland

[4] Tampere Univ Hosp, Dept Internal Med, Tampere, Finland

[5] Eastern Finland Lab Ctr, Kuopio, Finland

[6] Univ Turku, Lab Div, Turku Univ Hosp, Turku, Finland

[7] Univ Turku, Clin Chem, Fac Med, Turku, Finland

[8] Eksote Hosp Dist South Carelia, Valto Kakelan Katu 3, Lappeenranta 53130, Finland

来源：

CYTOKINE | 2020年 / 129卷

关键词：

Interleukin-18; Febrile neutropenia; Non-Hodgkin lymphoma; Acute myeloid leukemia; Multiple myeloma; SEVERE SEPSIS; SEPTIC SHOCK; CYTOKINES; RECEPTOR; IL-18;

D O I：

10.1016/j.cyto.2020.155021

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

In search of a biomarker for complicated course of febrile neutropenia (FN), plasma IL-18 was measured in 92 hematological patients after intensive chemotherapy at the beginning of FN (days 0-3). Complicated course was defined as blood culture positivity or septic shock. IL-18 varied according to background hematological malignancy and showed an inverse correlation with leukocyte count. IL-18 was not associated with complicated course of FN, defined as blood culture positivity or septic shock, in the whole study group, but an association was observed on d1 and d2 after the onset of FN in the subgroup of autologous stem cell transplant recipients with non-Hodgkin lymphoma.

引用

页数：4

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