Development of the innervation of the human inner ear

被引：16

作者：

Pechriggl, Elisabeth J. ^{[1
]}

Bitsche, Mario ^{[1
]}

Glueckert, Rudolf ^{[2
,3
]}

Rask-Andersen, Helge ^{[4
]}

Blumer, Michael J. F. ^{[1
]}

Schrott-Fischer, Annelies ^{[2
]}

Fritsch, Helga ^{[1
]}

机构：

[1] Med Univ Innsbruck, Dept Anat Histol & Embryol, Div Clin & Funct Anat, A-6020 Innsbruck, Austria

[2] Med Univ Innsbruck, Dept Otolaryngol, A-6020 Innsbruck, Austria

[3] Tiroler Landeskrankenanstalten, Univ Clin Innsbruck, Innsbruck, Austria

[4] Univ Uppsala Hosp, Dept Otolaryngol, S-75185 Uppsala, Sweden

来源：

DEVELOPMENTAL NEUROBIOLOGY | 2015年 / 75卷 / 07期

基金：

奥地利科学基金会;

关键词：

inner ear; early development; MAF B; glutamine synthetase; PAX2; BDNF; innervation; SPIRAL GANGLION NEURONS; INTERMEDIATE-FILAMENT PROTEIN; CELL RIBBON SYNAPSE; GUINEA-PIG COCHLEA; HAIR-CELLS; SENSORY EPITHELIA; AUDITORY-SYSTEM; POSTNATAL-DEVELOPMENT; SUPPORTING CELLS; MOUSE COCHLEA;

D O I：

10.1002/dneu.22242

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Studies on the formation of neuronal structures of the human cochlea are rare, presumptively, due to the difficult accessibility of specimens, so that most investigations are performed on mouse models. By means of immunohistochemical and transmission electron microscopic techniques, we investigated an uninterrupted series of unique specimens from gestational week 8 to week 12. We were able to demonstrate the presence of nerve fibers in the prosensory domain at gestational week 8, followed by afferent synaptogenesis at week 11. We identified PAX2 as an early marker for hair cell differentiation. Glutamine synthetase-positive peripheral glial cells occurred at the beginning of week 8. Transcription factor MAF B was used to demonstrate maturation of the spiral ganglion neurons. The early expression of tyrosine hydroxylase could be assessed. This study provides insights in the early assembly of the neural circuit and organization in humans. (c) 2014 Wiley Periodicals, Inc. Develop Neurobiol 75: 683-702, 2015

引用

页码：683 / 702

页数：20

共 106 条

[1] Development of an Innovative 3D Cell Culture System to Study Tumour - Stroma Interactions in Non-Small Cell Lung Cancer Cells [J].