Relationship Between Cortical Gyrification, White Matter Connectivity, and Autism Spectrum Disorder

被引：67

作者：

Ecker, C. ^{[1
,2
,3
]}

Andrews, D. ^{[1
,2
]}

Dell'Acqua, F. ^{[1
,2
]}

Daly, E. ^{[1
,2
]}

Murphy, C. ^{[1
,2
]}

Catani, M. ^{[1
,2
]}

Thiebaut de Schotten, M. ^{[1
,2
]}

Baron-Cohen, S. ^{[4
]}

Lai, M. C. ^{[4
,5
,6
,7
]}

Lombardo, M. V. ^{[4
,8
,9
]}

Bullmore, E. T. ^{[10
]}

Suckling, J. ^{[10
]}

Williams, S. ^{[11
]}

Jones, D. K. ^{[12
]}

Chiocchetti, A. ^{[3
]}

Murphy, D. G. M. ^{[1
,2
]}

机构：

[1] Kings Coll London, Dept Forens & Neurodev Sci, London SE5 8AF, England

[2] Kings Coll London, Inst Psychiat Psychol & Neurosci, Sackler Inst Translat Neurodev Sci, London SE5 8AF, England

[3] Goethe Univ Frankfurt, Dept Child & Adolescent Psychiat Psychosomat & Ps, D-60528 Frankfurt, Germany

[4] Univ Cambridge, Dept Psychiat, Autism Res Ctr, Cambridge CB2 8AH, England

[5] Univ Toronto, Ctr Addict & Mental Hlth, Child & YouthMental Hlth Collaborat, Toronto, ON M6J 1H4, Canada

[6] Univ Toronto, Hosp Sick Children, Dept Psychiat, Toronto, ON M6J 1H4, Canada

[7] Natl Taiwan Univ Hosp & Coll Med, Dept Psychiat, Taipei 100, Taiwan

[8] Univ Cyprus, Dept Psychol, CY-1678 Nicosia, Cyprus

[9] Univ Cyprus, Ctr Appl Neurosci, CY-1678 Nicosia, Cyprus

[10] Univ Cambridge, Dept Psychiat, Brain Mapping Unit, Cambridge CB2 0SZ, England

[11] Kings Coll London, Inst Psychiat Psychol & Neurosci, Ctr Neuroimaging Sci, London SE5 8AF, England

[12] Cardiff Univ, Sch Psychol, Brain Res Imaging Ctr, Cardiff CF24 5HQ, S Glam, Wales

来源：

CEREBRAL CORTEX | 2016年 / 26卷 / 07期

基金：

英国医学研究理事会;

关键词：

Autism spectrum disorder; brain anatomy; brain connectivity; brain development; multimodal neuroimaging; SURFACE-BASED ANALYSIS; VOLUME INCREASE; CORPUS-CALLOSUM; PROGENITOR-CELL; BRAIN; DIFFUSION; ABNORMALITIES; INDIVIDUALS; ADULTS; GENES;

D O I：

10.1093/cercor/bhw098

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Autism spectrum disorder (ASD) is a complex neurodevelopmental condition, which is accompanied by differences in gray matter neuroanatomy and white matter connectivity. However, it is unknown whether these differences are linked or reflect independent aetiologies. Using a multimodal neuroimaging approach, we therefore examined 51 male adults with ASD and 48 neurotypical controls to investigate the relationship between gray matter local gyrification (lGI) and white matter diffusivity in associated fiber tracts. First, ASD individuals had a significant increase in gyrification around the left pre- and post-central gyrus. Second, white matter fiber tracts originating and/or terminating in the cluster of increased lGI had a significant increase in axial diffusivity. This increase in diffusivity was predominantly observed in tracts in close proximity to the cortical sheet. Last, we demonstrate that the increase in lGI was significantly correlated with increased diffusivity of short tracts. This relationship was not significantly modulated by a main effect of group (i.e., ASD), which was more closely associated with gray matter gyrification than white matter diffusivity. Our findings suggest that differences in gray matter neuroanatomy and white matter connectivity are closely linked, and may reflect common rather than distinct aetiological pathways.

引用

页码：3297 / 3309

页数：13

共 86 条

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