Relating MEG measured motor cortical oscillations to resting γ-Aminobutyric acid (GABA) concentration

被引:239
作者
Gaetz, W. [1 ]
Edgar, J. C. [1 ]
Wang, D. J. [1 ]
Roberts, T. P. L. [1 ]
机构
[1] Childrens Hosp Philadelphia, Dept Radiol, Lurie Family Fdn MEG Imaging Ctr, Philadelphia, PA 19104 USA
关键词
Magnetic resonance spectroscopy (MRS); gamma-Aminobutyric acid (GABA); Event-related desynchrony/synchrony (ERD/ERS); MOVEMENT BETA-SYNCHRONIZATION; SENSORIMOTOR-CORTEX; HUMAN BRAIN; STIMULATION; FREQUENCY; AREA; LOCALIZATION; MODULATION; HUMANS; SYSTEM;
D O I
10.1016/j.neuroimage.2010.12.077
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
The human motor cortex exhibits characteristic beta (15-30 Hz) and gamma oscillations (60-90 Hz), typically observed in the context of transient finger movement tasks. The functional significance of these oscillations, such as post-movement beta rebound (PMBR) and movement-related gamma synchrony (MRGS) remains unclear. Considerable animal and human non-invasive studies, however, suggest that the networks supporting these motor cortex oscillations depend critically on the inhibitory neurotransmitter gamma-Aminobutyric acid (GABA). Despite such speculation, a direct relation between MEG measured motor cortex oscillatory power and frequency with resting GABA concentrations has not been demonstrated. In the present study, motor cortical responses were measured from 9 healthy adults while they performed a cued button-press task using their right index finger. In each participant, PMBR and MRGS measures were obtained from time-frequency plots obtained from primary motor (MI) sources, localized using beamformer differential source localization. For each participant, complimentary magnetic resonance spectroscopy (MRS) GABA measures aligned to the motor hand knob of the left central sulcus were also obtained. GABA concentration was estimated as the ratio of the motor cortex GABA integral to a cortical reference NAA resonance at 2 ppm. A significant linear relation was observed between MI GABA concentration and MRGS frequency (R(2) = 0.46, p<0.05), with no association observed between GABA concentration and MRGS power. Conversely, a significant linear relation was observed between MI GABA concentration and PMBR power (R(2) = 0.34, p<0.05). with no relation observed for GABA concentration and PMBR frequency. Finally, a significant negative linear relation between the participant's age and MI gamma frequency was observed, such that older participants had a lower gamma frequency (R(2) = 0.40, p<0.05). Present findings support a role for GABA in the generation and modulation of endogenous motor cortex rhythmic beta and gamma activity. (C) 2011 Elsevier Inc. All rights reserved.
引用
收藏
页码:616 / 621
页数:6
相关论文
共 28 条
[1]  
[Anonymous], 1999, FUNCTIONAL NEUROIMAG
[2]   Age-related changes in GABAA receptor subunit composition and function in rat auditory system [J].
Caspary, DM ;
Holder, TM ;
Hughes, LF ;
Milbrandt, JC ;
McKernan, RM ;
Naritoku, DK .
NEUROSCIENCE, 1999, 93 (01) :307-312
[3]   Does post-movement beta synchronization reflect an idling motor cortex? [J].
Cassim, F ;
Monaca, C ;
Szurhaj, W ;
Bourriez, JL ;
Defebvre, L ;
Derambure, P ;
Guieu, JD .
NEUROREPORT, 2001, 12 (17) :3859-3863
[4]   Modulation of motor cortex excitability by median nerve and digit stimulation [J].
Chen, R ;
Corwell, B ;
Hallett, M .
EXPERIMENTAL BRAIN RESEARCH, 1999, 129 (01) :77-86
[5]   Self-paced movements induce high-frequency gamma oscillations in primary motor cortex [J].
Cheyne, Douglas ;
Bells, Sonya ;
Ferrari, Paul ;
Gaetz, William ;
Bostan, Andreea C. .
NEUROIMAGE, 2008, 42 (01) :332-342
[6]   Diurnal Stability of γ-aminobutyric Acid Concentration in Visual and Sensorimotor Cortex [J].
Evans, Christopher John ;
McGonigle, David John ;
Edden, Richard Anthony Edward .
JOURNAL OF MAGNETIC RESONANCE IMAGING, 2010, 31 (01) :204-209
[7]   Localization of sensorimotor cortical rhythms induced by tactile stimulation using spatially filtered MEG [J].
Gaetz, W ;
Cheyne, D .
NEUROIMAGE, 2006, 30 (03) :899-908
[8]   Neuromagnetic imaging of movement-related cortical oscillations in children and adults: Age predicts post-movement beta rebound [J].
Gaetz, W. ;
MacDonald, M. ;
Cheyne, D. ;
Snead, O. C. .
NEUROIMAGE, 2010, 51 (02) :792-807
[9]   Aging alters regional multichemical profile of the human brain:: an in vivo 1H-MRS study of young versus middle-aged subjects [J].
Grachev, ID ;
Apkarian, AV .
JOURNAL OF NEUROCHEMISTRY, 2001, 76 (02) :582-593
[10]   Neuronal Network Pharmacodynamics of GABAergic Modulation in the Human Cortex Determined Using Pharmaco-Magnetoencephalography [J].
Hall, Stephen D. ;
Barnes, Gareth R. ;
Furlong, Paul L. ;
Seri, Stefano ;
Hillebrand, Arjan .
HUMAN BRAIN MAPPING, 2010, 31 (04) :581-594