Caspase activation precedes and leads to neurodegeneration in a marine model of Alzheimer's disease

被引：3
作者：
de Calignon, Alix [1 ]
Spires-Jones, Tara L. [1 ]
Hyman, Bradley T. [1 ]
机构：
[1] Mass Gen Inst Neurodegenerat Dis, Charlestown, MA 02129 USA
来源：
M S-MEDECINE SCIENCES | 2010年 / 26卷 / 10期
关键词：
TANGLE-BEARING NEURONS; NEUROFIBRILLARY TANGLES; MOUSE MODEL; TAU; PLAQUES;
D O I：
10.1051/medsci/20102610787
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
引用
收藏
页码：787 / 789
页数：3
相关论文
共 14 条
  • [1] Specific tau phosphorylation sites correlate with severity of neuronal cytopathology in Alzheimer's disease
    Augustinack, JC
    Schneider, A
    Mandelkow, EM
    Hyman, BT
    [J]. ACTA NEUROPATHOLOGICA, 2002, 103 (01) : 26 - 35
  • [2] Imaging of amyloid-β deposits in brains of living mice permits direct observation of clearance of plaques with immunotherapy
    Backskai, BJ
    Kajdasz, ST
    Christie, RH
    Carter, C
    Games, D
    Seubert, P
    Schenk, D
    Hyman, BT
    [J]. NATURE MEDICINE, 2001, 7 (03) : 369 - 372
  • [3] Induction and spreading of tau pathology in a mouse model of Alzheimer's disease
    Clavaguera, Florence
    Goedert, Michel
    ToInay, Markus
    [J]. M S-MEDECINE SCIENCES, 2010, 26 (02): : 121 - 124
  • [4] Caspase activation precedes and leads to tangles
    de Calignon, Alix
    Fox, Leora M.
    Pitstick, Rose
    Carlson, George A.
    Bacskai, Brian J.
    Spires-Jones, Tara L.
    Hyman, Bradley T.
    [J]. NATURE, 2010, 464 (7292) : 1201 - U123
  • [5] Tangle-Bearing Neurons Survive Despite Disruption of Membrane Integrity in a Mouse Model of Tauopathy
    de Calignon, Alix
    Spires-Jones, Tara L.
    Pitstick, Rose
    Carlson, George A.
    Hyman, Bradley T.
    [J]. JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY, 2009, 68 (07) : 757 - 761
  • [6] Diagnosis and staging of Alzheimer disease
    Duyckaerts, C
    Hauw, JJ
    [J]. NEUROBIOLOGY OF AGING, 1997, 18 (04) : S33 - S42
  • [7] Neuronal loss correlates with but exceeds neurofibrillary tangles in Alzheimer's disease
    GomezIsla, T
    Hollister, R
    West, H
    Mui, S
    Growdon, JH
    Petersen, RC
    Parisi, JE
    Hyman, BT
    [J]. ANNALS OF NEUROLOGY, 1997, 41 (01) : 17 - 24
  • [8] AN IMPROVED THIOFLAVINE-S METHOD FOR STAINING NEUROFIBRILLARY TANGLES AND SENILE PLAQUES IN ALZHEIMERS-DISEASE
    GUNTERN, R
    BOURAS, C
    HOF, PR
    VALLET, PG
    [J]. EXPERIENTIA, 1992, 48 (01): : 8 - 10
  • [9] Active caspase-6 and caspase-6-cleaved Tau in neuropil threads, neuritic plaques, and neurofibrillary tangles of Alzheimer's disease
    Guo, HS
    Albrecht, S
    Bourdeau, M
    Petzke, T
    Bergeron, C
    LeBlanc, AC
    [J]. AMERICAN JOURNAL OF PATHOLOGY, 2004, 165 (02) : 523 - 531
  • [10] Medicine - The amyloid hypothesis of Alzheimer's disease: Progress and problems on the road to therapeutics
    Hardy, J
    Selkoe, DJ
    [J]. SCIENCE, 2002, 297 (5580) : 353 - 356
12