The effects of CA1 5HT4 receptors in MK801-induced amnesia and hyperlocomotion

被引：22

作者：

Nasehi, Mohammad ^{[1
,2
]}

Tabatabaie, Maryam ^{[3
]}

Khakpai, Fatemeh ^{[3
]}

Zarrindast, Mohammad-Reza ^{[1
,2
,3
,4
,5
,6
]}

机构：

[1] Islamic Azad Univ, Med Genom Res Ctr, Tehran, Iran

[2] Islamic Azad Univ, Sch Adv Sci Med, Tehran Med Sci Branch, Tehran, Iran

[3] ICSS, Tehran, Iran

[4] Univ Tehran Med Sci, Sch Med, Dept Pharmacol, Tehran, Iran

[5] Univ Tehran Med Sci, Sch Med, Iranian Natl Ctr Addict Studies, Tehran, Iran

[6] Inst Res Fundamental Sci IPM, Sch Cognit Sci, Tehran, Iran

来源：

NEUROSCIENCE LETTERS | 2015年 / 587卷

关键词：

5-HT4; Receptor; MK801; CA1; Memory; INDUCED MEMORY IMPAIRMENT; NMDA RECEPTOR; MK-801-INDUCED LOCOMOTION; SEROTONIN RECEPTORS; 5-HT1A RECEPTORS; MK-801; ENHANCEMENT; HIPPOCAMPUS; INVOLVEMENT; ANTAGONIST;

D O I：

10.1016/j.neulet.2014.12.019

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

In this study, the effects of 5-HT4 receptors of the CA1 on MK801-induced amnesia and hyperlocomotion were examined. One-trial step-down method was used to assess memory retention and then, the hole-board method to assess exploratory behaviors. The results showed that post-training intra-CA1 administration of RS67333 (62.5 and 625 ng/mouse) and RS23597 (1 and 10 ng/mouse) decreased memory consolidation, but it did not alter head-dip counts, head-dip latency and locomotor activity. Similarly, MK801 (0.5 and 1 mu g/mouse) decreased memory consolidation, but had no effect on head-dip counts and head-dip latency. Interestingly, it increased locomotor activity. The results also showed that post-training intra-CA1 injection of a sub-threshold dose of RS67333 (6.25 ng/mouse) or RS23597 (0.1 ng/mouse) could heighten MK801 induced amnesia and decrease locomotor activity, but it did not alter head-dip counts and head-dip latency. In conclusion, our findings suggest that the CA1 5-HT4 receptors are involved in MK801-induced amnesia and hyperlocomotion. (C) 2014 Elsevier Ireland Ltd. All rights reserved.

引用

页码：73 / 78

页数：6

共 42 条

[1] Stimulation of basolateral amygdaloid serotonin 5-HT2C receptors promotes the induction of long-term potentiation in the dentate gyrus of anesthetized rats
Abe, Kazuho
Fujimoto, Taiki
Akaishi, Tatsuhiro
Misawa, Miwa
[J]. NEUROSCIENCE LETTERS, 2009, 451 (01) : 65 - 68
[2] Ataee R, 2010, ARCH IRAN MED, V13, P120
[3] Enhancement of long-term potentiation at CA1-subiculum synapses in MK-801-treated rats
Buck, N
Cali, S
Behr, J
[J]. NEUROSCIENCE LETTERS, 2006, 392 (1-2) : 5 - 9
[4] The human hippocampus and spatial and episodic memory
Burgess, N
Maguire, EA
O'Keefe, J
[J]. NEURON, 2002, 35 (04) : 625 - 641
[5] ERK1/2 and CaMKII-mediated events in memory formation: Is 5HT regulation involved?
Cammarota, Martin
Bevilaqua, Lia R.
Medina, Jorge H.
Izquierdo, Ivan
[J]. BEHAVIOURAL BRAIN RESEARCH, 2008, 195 (01) : 120 - 128
[6] Differential role of the basolateral amygdala 5-HT3 and 5-HT4 serotonin receptors upon ACPA-induced anxiolytic-like behavidrs and emotional memory deficit in mice
Chegini, Hamid-Reza
Nasehi, Mohammad
Zarrindast, Mohammad-Reza
[J]. BEHAVIOURAL BRAIN RESEARCH, 2014, 261 : 114 - 126
[7] Serotonin Receptors in Hippocampus
Cristina Berumen, Laura
Rodriguez, Angelina
Miledi, Ricardo
Garcia-Alcocer, Guadalupe
[J]. SCIENTIFIC WORLD JOURNAL, 2012,
[8] Pre- or post-training administration of the NMDA receptor blocker MK-801 impairs object recognition memory in rats
de Lima, MNM
Laranja, DC
Bromberg, E
Roesler, R
Schröder, N
[J]. BEHAVIOURAL BRAIN RESEARCH, 2005, 156 (01) : 139 - 143
[9] 5-HT2A receptor activation in the dorsolateral septum facilitates inhibitory avoidance in the elevated T-maze
de Paula, D. C.
Torricelli, A. S.
Lopreato, M. R.
Nascimento, J. O. G.
Viana, M. B.
[J]. BEHAVIOURAL BRAIN RESEARCH, 2012, 226 (01) : 50 - 55
[10] Harmaline competitively inhibits [H-3]MK-801 binding to the NMDA receptor in rabbit brain
Du, W
Aloyo, VJ
Harvey, JA
[J]. BRAIN RESEARCH, 1997, 770 (1-2) : 26 - 29

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