Oxidative Dearomative Cross-Dehydrogenative Coupling of Indoles with Diverse C-H Nucleophiles: Efficient Approach to 2,2-Disubstituted Indolin-3-ones

被引：16

作者：

Yan, Xue ^{[1
,2
]}

Tang, Ying-De ^{[1
,2
]}

Jiang, Cheng-Shi ^{[2
]}

Liu, Xigong ^{[2
,3
]}

Zhang, Hua ^{[2
]}

机构：

[1] Univ Jinan, Sch Chem & Chem Engn, Jinan 250022, Peoples R China

[2] Univ Jinan, Sch Biol Sci & Technol, Jinan 250022, Peoples R China

[3] Shandong Univ, Sch Chem & Chem Engn, Jinan 250100, Peoples R China

来源：

MOLECULES | 2020年 / 25卷 / 02期

基金：

中国国家自然科学基金;

关键词：

cross coupling; dearomatization; C-H functionalization; indolin-3-ones; dimerization and trimerization of indoles; MARINE-DERIVED FUNGUS; AEROBIC OXYGENATION; REDOX ANNULATION; BENZYLIC ETHERS; CONSTRUCTION; ALKALOIDS; CASCADE; QUATERNARY; ROUTE; FUNCTIONALIZATION;

D O I：

10.3390/molecules25020419

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The oxidative, dearomative cross-dehydrogenative coupling of indoles with various C-H nucleophiles is developed. This process features a broad substrate scope with respect to both indoles and nucleophiles, affording structurally diverse 2,2-disubstituted indolin-3-ones in high yields (up to 99%). The oxidative dimerization and trimerization of indoles has also been demonstrated under the same conditions.

引用

页数：22

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