A Randomized Placebo-Controlled Cross-Over Pilot Study of Riluzole for Drug-Refractory Irritability in Autism Spectrum Disorder

被引:19
作者
Wink, Logan K. [1 ]
Adams, Ryan [1 ]
Horn, Paul S. [1 ]
Tessier, Charles R. [2 ]
Bantel, Andrew P. [2 ]
Hong, Michael [1 ]
Shaffer, Rebecca C. [1 ]
Pedapati, Ernest V. [1 ]
Erickson, Craig A. [1 ]
机构
[1] Univ Cincinnati, Coll Med, Cincinnati Childrens Hosp Med Ctr, 3333 Burnet Ave MLC 4002, Cincinnati, OH 45229 USA
[2] Indiana Univ Sch Med, Indianapolis, IN 46202 USA
关键词
Autism; Autism spectrum disorder; Riluzole; Irritability; Extracellular signal related kinase; ERK; OBSESSIVE-COMPULSIVE DISORDER; OPEN-LABEL TRIAL; AGENT RILUZOLE; CHILDREN; AUGMENTATION; ACTIVATION; DEPRESSION; BRAIN; ARIPIPRAZOLE; ASSOCIATION;
D O I
10.1007/s10803-018-3562-5
中图分类号
B844 [发展心理学(人类心理学)];
学科分类号
040202 ;
摘要
Riluzole is a glutamatergic modulator of particular interest in autism spectrum disorder (ASD). In this 12-week randomized, double-blind, placebo-controlled, crossover pilot study we evaluated the safety and tolerability of 5-week of adjunctive riluzole treatment (vs. 5-week of placebo, with 2-week washout period) targeting ASD-associated drug-refractory irritability in eight individuals age 12-25 years. All participants tolerated riluzole 200 mg per day, however there were no statistically significant findings for the overall treatment effect, the treatment effect by week within period of the study, or a cross-over effect across the periods of the study on the Clinical Global Impression Improvement Scale or the Aberrant Behavior Checklist Irritability subscale. The results of this trial indicate that 5-week of riluzole treatment was well tolerated, but had no significant effect on the target symptoms. Trial Registration ClinicalTrials.gov Identifier NCT02081027, Registered 5 August 2013, First participant enrolled 19 September 2013.
引用
收藏
页码:3051 / 3060
页数:10
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