Cellular choreography in the germinal center: new visions from in vivo imaging

被引：11

作者：

Hauser, Anja E. ^{[2
]}

Kerfoot, Steven M. ^{[1
]}

Haberman, Ann M. ^{[1
]}

机构：

[1] Yale Univ, Sch Med, Dept Lab Med, New Haven, CT 06520 USA

[2] Deutsch Rheuma Forschungszentrum DRFZ, D-10117 Berlin, Germany

来源：

SEMINARS IN IMMUNOPATHOLOGY | 2010年 / 32卷 / 03期

关键词：

Germinal center; Lymphocyte; Migration; Follicular dendritic cell; Two-photon laser scanning microscopy; FOLLICULAR DENDRITIC CELLS; CENTER B-CELLS; CLASS-SWITCH RECOMBINATION; PRIMARY IMMUNE-RESPONSE; SUBCAPSULAR SINUS MACROPHAGES; DEPENDENT ANTIBODY-RESPONSES; ANTIGEN-DRIVEN SELECTION; CXC CHEMOKINE RECEPTOR-5; HELPER T-CELLS; AFFINITY MATURATION;

D O I：

10.1007/s00281-010-0214-z

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Germinal centers (GC) are large aggregates of proliferating B lymphocytes within follicles of lymphoid tissue that form during adaptive immune responses. GCs are the source of long-lived B cells that form the basis for pathogen-specific lifelong B cell immunity. The complex architecture of these structures includes subdomains that differ significantly in their stromal cell and T lymphocyte subset composition. In part due to their structural complexity and potential to generate some lymphomas, much interest and many theories about GC dynamics have emerged. Here, we review recent research employing in vivo imaging that has begun to untangle some of the mysteries.

引用

页码：239 / 255

页数：17

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