British Society for Histocompatibility & Immunogenetics and British Transplantation Society Guidelines for the Detection and Characterisation of Clinically Relevant Antibodies in Allotransplantation

被引：24

作者：

Howell, W. M. ^{[1
]}

Harmer, A. ^{[2
]}

Briggs, D. ^{[3
]}

Dyer, P. ^{[4
]}

Fuggle, S. V. ^{[5
]}

Martin, S. ^{[6
]}

Sinnott, P. ^{[7
,8
]}

Smith, J. ^{[9
]}

Taylor, C. J. ^{[10
]}

Vaughan, R. ^{[11
]}

机构：

[1] NHS Blood & Transplant, Dept Histocompatibil & Immunogenet, Newcastle Upon Tyne NE2 4NQ, Tyne & Wear, England

[2] NHS Blood & Transplant, Dept Histocompatibil & Immunogenet, Sheffield, S Yorkshire, England

[3] NHS Blood & Transplant, Dept Histocompatibil & Immunogenet, Birmingham, W Midlands, England

[4] SNBTS Clin Directorate, Royal Infirm Edinburgh, Edinburgh, Midlothian, Scotland

[5] Churchill Hosp, Oxford Transplant Ctr, Transplant Immunol & Immunogenet Lab, Oxford OX3 7LJ, England

[6] Manchester Royal Infirm, Transplant Lab, Manchester M13 9WL, Lancs, England

[7] Royal London Hosp, Clin Transplantat Lab, London, England

[8] Royal London Hosp, Barts & London NHS Trust, London, England

[9] Harefield Hosp, Heart Sci Ctr, Tissue Typing Lab, Harefield UB9 6JH, Middx, England

[10] Addenbrookes Hosp, Tissue Typing Lab, Cambridge Univ Hosp NHS Fdn Trust, Cambridge, England

[11] Guys Hosp, Clin Transplantat Lab, London SE1 9RT, England

来源：

INTERNATIONAL JOURNAL OF IMMUNOGENETICS | 2010年 / 37卷 / 06期

基金：

英国医学研究理事会;

关键词：

D O I：

10.1111/j.1744-313X.2010.00955.x

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

P>Ongoing technological developments in antibody detection and characterisation allowing relative quantitation of HLA-specific antibody levels, combined with crossmatch results, now allow a graded assessment of patient potential donor immunological risk for allotransplantation, rather than a simple 'positive' or 'negative' categorization of crossmatch results. These developments have driven a thorough revision of the British Society for Histocompatibility & Immunogenetics and British Transplantation Society Guidelines for the Detection and Characterisation of Clinically Relevant Antibodies in Allotransplantation. These newly published revised Guidelines contain a number of recommendations as to best practice for antibody detection and crossmatching for the transplantation of a wide range of solid organs and tissues. These recommendations are briefly summarized in this article.

引用

页码：435 / 437

页数：3