Tumor-Infiltrating Lymphocytes in Breast Cancer. Association with Clinical and Pathological Parameters

被引：3

作者：

Zabotina, T. N. ^{[1
]}

Korotkova, O. V. ^{[1
]}

Chertkova, A. I. ^{[1
]}

Zakharova, E. N. ^{[1
]}

Tabakov, D. V. ^{[1
]}

Dzhgamadze, N. T. ^{[1
]}

Savostikova, M. V. ^{[1
]}

Artamonova, E. V. ^{[1
]}

Khailenko, V. A. ^{[1
]}

Kovalenko, E. I. ^{[1
]}

Kadagidze, Z. G. ^{[1
]}

机构：

[1] Minist Hlth Russian Federat, NN Blokhin Natl Med Res Ctr Oncol, Moscow, Russia

来源：

BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE | 2018年 / 166卷 / 02期

关键词：

breast cancer; Ki-67%; estrogen and progesterone receptors; tumor-infiltrating lymphocytes; DEPENDS;

D O I：

10.1007/s10517-018-4323-3

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

In patients with primary resectable breast cancer, a positive correlation between the age and the count of CD16(+) lymphocytes and a negative correlation of this parameter with the number of regulatory CD4(+)CD25(+)CD127 cells and proliferative activity of Ki-67 tumor cells were revealed. Higher level of Ki-67 was associated with reduced number of effector lymphocytes (CD8(+) and CD16(+)) and elevated content of regulatory CD8(+)CD11bCD28 T cells. The absence of expression of estrogen receptors was associated with reduced cytotoxic potential of CD8(+) T cell in comparison with ER+ breast cancer. The percentage of CD8(+) lymphocytes (CD3(+)CD8(+) and CD8(+)CD11b(+)CD28(+)) among lymphocytes infiltrating the tumor was higher in PR+ breast cancer than in PR tumors. With increasing the tumor load, the number of lymphocytes expressing CD16 marker and their cytotoxic potential decreased.

引用

页码：241 / 244

页数：4

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