Design, synthesis and preliminary antiviral screening of new N-phenylpyrazole and dihydroisoxazole derivatives

被引：13

作者：

Rashad, Adel A. ^{[1
]}

El-Sabbagh, Osama I. ^{[1
]}

Baraka, Mohamed M. ^{[1
]}

Ibrahim, Samy M. ^{[1
]}

Pannecouque, Christophe ^{[2
]}

Andrei, Graciela ^{[2
]}

Snoeck, Robert ^{[2
]}

Balzarini, Jan ^{[2
]}

Mostafa, Ahmed ^{[3
]}

机构：

[1] Zagazig Univ, Dept Med Chem, Fac Pharm, Zagazig 44511, Egypt

[2] Katholieke Univ Leuven, Rega Inst Med Res, Fac Med, Louvain, Belgium

[3] Natl Res Ctr, Environm Virol Lab, Dept Water Pollut, Dokki, Egypt

来源：

MEDICINAL CHEMISTRY RESEARCH | 2010年 / 19卷 / 09期

关键词：

Synthesis; Antiviral activity; N-phenylpyrazoles; Dihydroisoxazole; Herpes simplex virus type 1; Hepatitis A virus; ASSAY; ARYL; ACID;

D O I：

10.1007/s00044-009-9248-y

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A new series of N-phenylpyrazoles and dihydroisoxazles was synthesized starting from alpha,beta-unsaturated ketones in basic media using phenyl hydrazine and hydroxylamine HCl, respectively. Antiviral evaluation of the target compounds revealed that the dihydroisoxazole derivatives have promising antiviral activity against hepatitis A virus and herpes simplex virus type 1.

引用

页码：1025 / 1035

页数：11

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