Direct carbon-carbon bond formation via soft enolization: aldol addition of α-halogenated thioesters

被引：12
|
作者：
Yost, Julianne M. [1 ]
Alfie, Rachel J. [1 ]
Tarsis, Emily M. [1 ]
Chong, Insun [1 ]
Coltart, Don M. [1 ]
机构：
[1] Duke Univ, Dept Chem, Durham, NC 27706 USA
来源：
CHEMICAL COMMUNICATIONS | 2011年 / 47卷 / 01期
基金：
美国国家科学基金会;
关键词：
DARZENS; ACIDS; TRIETHYLAMINE; 1,3-DIKETONES; CONDENSATION; KETONES; FACILE; ESTERS;
D O I：
10.1039/c0cc02345k
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
alpha-Halo thioesters undergo soft enolization and syn-selective direct aldol addition to aldehydes in the presence of MgBr(2)center dot OEt(2) and i-Pr(2)NEt to produce alpha-halo-beta-hydroxy thioesters.
引用
收藏
页码：571 / 572
页数：2
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