Efficacy and Mechanism of Traditional Medicinal Plants and Bioactive Compounds against Clinically Important Pathogens

被引:104
作者
Mickymaray, Suresh [1 ]
机构
[1] Al Zulfi Majmaah Univ, Dept Biol, Coll Sci, Majmaah 11952, Saudi Arabia
来源
ANTIBIOTICS-BASEL | 2019年 / 8卷 / 04期
关键词
traditional medicinal plants; bioactive compounds; antimicrobial activities; mechanisms; ISORA BARK EXTRACTS; ANTIMICROBIAL ACTIVITY; STAPHYLOCOCCUS-AUREUS; BIOFILM FORMATION; EPIGALLOCATECHIN GALLATE; ANTIBACTERIAL ACTIVITY; ANTIFUNGAL ACTIVITY; ESSENTIAL OIL; ANTIFOLATE ACTIVITY; LIPID-PEROXIDATION;
D O I
10.3390/antibiotics8040257
中图分类号
R51 [传染病];
学科分类号
100401 ;
摘要
Traditional medicinal plants have been cultivated to treat various human illnesses and avert numerous infectious diseases. They display an extensive range of beneficial pharmacological and health effects for humans. These plants generally synthesize a diverse range of bioactive compounds which have been established to be potent antimicrobial agents against a wide range of pathogenic organisms. Various research studies have demonstrated the antimicrobial activity of traditional plants scientifically or experimentally measured with reports on pathogenic microorganisms resistant to antimicrobials. The antimicrobial activity of medicinal plants or their bioactive compounds arising from several functional activities may be capable of inhibiting virulence factors as well as targeting microbial cells. Some bioactive compounds derived from traditional plants manifest the ability to reverse antibiotic resistance and improve synergetic action with current antibiotic agents. Therefore, the advancement of bioactive-based pharmacological agents can be an auspicious method for treating antibiotic-resistant infections. This review considers the functional and molecular roles of medicinal plants and their bioactive compounds, focusing typically on their antimicrobial activities against clinically important pathogens.
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页数:57
相关论文
共 173 条
[1]   Artemisia herba-alba essential oil from Buseirah (South Jordan): Chemical characterization and assessment of safe antifungal and anti-inflammatory doses [J].
Abu-Darwish, M. S. ;
Cabral, C. ;
Goncalves, M. J. ;
Cavaleiro, C. ;
Cruz, M. T. ;
Efferth, T. ;
Salgueiro, L. .
JOURNAL OF ETHNOPHARMACOLOGY, 2015, 174 :153-160
[2]   Pharmacologically active flavonoids from the anticancer, antioxidant and antimicrobial extracts of Cassia angustifolia Vahl [J].
Ahmed, Shabina Ishtiaq ;
Hayat, Muhammad Qasim ;
Tahir, Muhammad ;
Mansoor, Qaisar ;
Ismail, Muhammad ;
Keck, Kristen ;
Bates, Robert B. .
BMC COMPLEMENTARY AND ALTERNATIVE MEDICINE, 2016, 16
[3]   An in vitro investigation of indigenous South African medicinal plants used to treat oral infections [J].
Akhalwaya, S. ;
van Vuuren, S. ;
Patel, M. .
JOURNAL OF ETHNOPHARMACOLOGY, 2018, 210 :359-371
[4]   GC-MS-based metabolomics, antibacterial and anti-inflammatory investigations to characterize the quality of essential oil obtained from dried Xylopia aethiopica fruits from Ghana and Nigeria [J].
Alolga, Raphael N. ;
Leon, Maria A. S. C. Chavez ;
Osei-Adjei, George ;
Onoja, Vitus .
JOURNAL OF PHARMACY AND PHARMACOLOGY, 2019, 71 (10) :1544-1552
[5]   Phytochemical Characteristics and Antimicrobial Activity of Australian Grown Garlic (Allium Sativum L.) Cultivars [J].
Anh Dao Thi Phan ;
Netzel, Gabriele ;
Chhim, Panhchapor ;
Netzel, Michael E. ;
Sultanbawa, Yasmina .
FOODS, 2019, 8 (09)
[6]  
[Anonymous], MALAYS J MICROBIOL
[7]  
[Anonymous], 2012, J MED PLANTS RES
[8]  
[Anonymous], 2016, APPL MED RES, DOI DOI 10.5455/AMR.20161012082036
[9]  
[Anonymous], BANGLADESH J PLANT T
[10]  
[Anonymous], 2014, BMC INFECT DIS