Scaffolding to build a rational vaccine design strategy

被引：50
作者：
Burton, Dennis R. [1 ,2 ,3 ,4 ]
机构：
[1] Scripps Res Inst, Dept Immunol & Microbial Sci, La Jolla, CA 92037 USA
[2] Scripps Res Inst, Int AIDS Vaccine Initiat Neutralizing Antibody Ct, La Jolla, CA 92037 USA
[3] Massachusetts Gen Hosp, Ragon Inst, MIT, Boston, MA 02114 USA
[4] Harvard Univ, Boston, MA 02114 USA
来源：
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 2010年 / 107卷 / 42期
关键词：
IMMUNODEFICIENCY-VIRUS TYPE-1; COMPLEMENTARITY-DETERMINING REGION; PROXIMAL EXTERNAL REGION; ANTIBODY; 2F5; MONOCLONAL-ANTIBODY; HEAVY-CHAIN; GP41; EPITOPE; HIV-1; AUTOREACTIVITY;
D O I：
10.1073/pnas.1012923107
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
引用
收藏
页码：17859 / 17860
页数：2
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共 21 条
  • [1] Confocal microscopy of giant vesicles supports the absence of HIV-1 neutralizing 2F5 antibody reactivity to plasma membrane phospholipids
    Apellaniz, Beatriz
    Garcia-Saez, Ana J.
    Huarte, Nerea
    Kunert, Renate
    Vorauer-Uhl, Karola
    Katinger, Hermann
    Schwille, Petra
    Nieva, Jose L.
    [J]. FEBS LETTERS, 2010, 584 (08) : 1591 - 1596
  • [2] Antibodies, viruses and vaccines
    Burton, DR
    [J]. NATURE REVIEWS IMMUNOLOGY, 2002, 2 (09) : 706 - 713
  • [3] Broadly neutralizing anti-HIV antibody 4E10 recognizes a helical conformation of a highly conserved fusion-associated motif in gp41
    Cardoso, RMF
    Zwick, MB
    Stanfield, RL
    Kunert, R
    Binley, JM
    Katinger, H
    Burton, DR
    Wilson, IA
    [J]. IMMUNITY, 2005, 22 (02) : 163 - 173
  • [4] Computational Design of Epitope-Scaffolds Allows Induction of Antibodies Specific for a Poorly Immunogenic HIV Vaccine Epitope
    Correia, Bruno E.
    Ban, Yih-En Andrew
    Holmes, Margaret A.
    Xu, Hengyu
    Ellingson, Katharine
    Kraft, Zane
    Carrico, Chris
    Boni, Erica
    Sather, D. Noah
    Zenobia, Camille
    Burke, Katherine Y.
    Bradley-Hewitt, Tyler
    Bruhn-Johannsen, Jessica F.
    Kalyuzhniy, Oleksandr
    Baker, David
    Strong, Roland K.
    Stamatatos, Leonidas
    Schief, William R.
    [J]. STRUCTURE, 2010, 18 (09) : 1116 - 1126
  • [5] Cardiolipin polyspecific autoreactivity in two broadly neutralizing HIV-1 antibodies
    Haynes, BF
    Fleming, J
    St Clair, EW
    Katinger, H
    Stiegler, G
    Kunert, R
    Robinson, J
    Scearce, RM
    Plonk, K
    Staats, HF
    Ortel, TL
    Liao, HX
    Alam, SM
    [J]. SCIENCE, 2005, 308 (5730) : 1906 - 1908
  • [6] Broadly Neutralizing Monoclonal Antibodies 2F5 and 4E10 Directed against the Human Immunodeficiency Virus Type 1 gp41 Membrane-Proximal External Region Protect against Mucosal Challenge by Simian-Human Immunodeficiency Virus SHIVBa-L
    Hessell, Ann J.
    Rakasz, Eva G.
    Tehrani, David M.
    Huber, Michael
    Weisgrau, Kimberly L.
    Landucci, Gary
    Forthal, Donald N.
    Koff, Wayne C.
    Poignard, Pascal
    Watkins, David I.
    Burton, Dennis R.
    [J]. JOURNAL OF VIROLOGY, 2010, 84 (03) : 1302 - 1313
  • [7] Ablation of the Complementarity-Determining Region H3 Apex of the Anti-HIV-1 Broadly Neutralizing Antibody 2F5 Abrogates Neutralizing Capacity without Affecting Core Epitope Binding
    Julien, Jean-Philippe
    Huarte, Nerea
    Maeso, Ruben
    Taneva, Stefka G.
    Cunningham, Annie
    Nieva, Jose L.
    Pai, Emil F.
    [J]. JOURNAL OF VIROLOGY, 2010, 84 (09) : 4136 - 4147
  • [8] Structural Details of HIV-1 Recognition by the Broadly Neutralizing Monoclonal Antibody 2F5: Epitope Conformation, Antigen-Recognition Loop Mobility, and Anion-Binding Site
    Julien, Jean-Philippe
    Bryson, Steve
    Nieva, Jose L.
    Pai, Emil F.
    [J]. JOURNAL OF MOLECULAR BIOLOGY, 2008, 384 (02) : 377 - 392
  • [9] The Role of Antibodies in HIV Vaccines
    Mascola, John R.
    Montefiori, David C.
    [J]. ANNUAL REVIEW OF IMMUNOLOGY, VOL 28, 2010, 28 : 413 - 444
  • [10] Lipid binding properties of 4E10, 2175, and WR304 monoclonal antibodies that neutralize HIV-1
    Matyas, Gary R.
    Beck, Zoltan
    Karasawas, Nicos
    Alving, Carl R.
    [J]. BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES, 2009, 1788 (03): : 660 - 665
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