Crumpled Graphene/Poly (azure I) Modified Electrode for Non-enzymatic Detection of Hydrogen Peroxide Secreted from Tumor Cells

被引：2

作者：

Zhang, Keying ^{[1
,2
]}

Zhang, Ziqiang ^{[1
]}

Ma, Shangshang ^{[1
]}

Cheng, Deshun ^{[1
]}

Fan, Mengdi ^{[1
]}

Zhou, Xinyu ^{[1
]}

Li, Fajun ^{[1
]}

Zhang, Na ^{[1
]}

机构：

[1] Suzhou Univ, Sch Chem & Chem Engn, Anhui Key Lab Spin Electron & Nanomat, Suzhou 234000, Anhui, Peoples R China

[2] Chinese Acad Sci, Shanghai Inst Microsyst & Informat Technol, State Key Lab Transducer Technol, Shanghai 200050, Peoples R China

来源：

ANALYTICAL SCIENCES | 2021年 / 37卷 / 10期

关键词：

Graphene; hydrogen peroxide; poly (azure I); modified electrode; ELECTROCHEMICAL DETECTION; H2O2; DETECTION; OXIDE; ENZYME; NANOCOMPOSITES; NANOPARTICLES; FABRICATION; NANOFIBERS;

D O I：

10.2116/analsci.21P003

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

Hydrogen peroxide (H2O2), an important representatives of reactive oxygen species, its aberrant expression is related to many diseases, including cancers. Therefore, it is very significant to design a reliable method for the real-time detection of endogenous H2O2. Herein, we describe preparing a poly (azure I)/crumpled graphene (cGN) modified electrode by an electro-polymerization method. The results showed that this electrode presented obvious electrocatalytic effect on the reduction of H2O2. Amperometric method was employed to monitor H2O2, and the amperometric response exhibited a good linear relationship with its concentration in the range of 8.0 x 10(-6) - 1.25 x 10(-3) mol/L; the detection limit reached to 6.7 x 10(-7) mol/L (S/N = 3). Furthermore, this modified also displayed good selectivity, long-term stability and a high anti-interference ability. Excitingly, the established method could be successfully used to detect H2O2 in human serum samples, and measured H2O2 secreted from living MCF-7 cells. It could have potential use in cancer diagnosis.

引用

页码：1367 / 1372

页数：6

共 34 条

[1] Ex Situ Synthesis of Hexagonal NiO Nanosheets and Carboxyl-Terminated Reduced Graphene Oxide Nanocomposite for Non-Enzymatic Electrochemical Detection of H2O2 and Ascorbic Acid [J].