Synthesis of 1-arylcytosine-5-carboxylic acid esters

被引：5

作者：

Dorokhov, V. A. ^{[1
]}

Voronkova, V. A. ^{[1
]}

Komkov, A. V. ^{[1
]}

Baranin, S. V. ^{[1
]}

Vasil'ev, L. S. ^{[1
]}

机构：

[1] Russian Acad Sci, ND Zelinskii Organ Chem Inst, Moscow 119991, Russia

来源：

RUSSIAN CHEMICAL BULLETIN | 2010年 / 59卷 / 05期

关键词：

2-(diaminomethylidene)-3-oxobutanoic and 2-(diaminomethylidene)-3-oxo-3-phenylpropanoic acid esters; arylisocyanates; 1-arylcytosine-5-carboxylic acid esters; pyrimido-[4,5-d]pyrimidine-2,4,7(1H,3H,6H)-triones; base-catalyzed intramolecular cyclization; BETA-DICARBONYL COMPOUNDS; MICROWAVE IRRADIATION; CYTOSINE; DIACETYLKETENE; N; S-ACETALS; N-ACETALS; DERIVATIVES; ISOCYANATES; ANALOGS; SYSTEM;

D O I：

10.1007/s11172-010-0201-5

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A reaction of alkyl 2-(diaminomethylidene)-3-oxoalkanoates with arylisocyanates leads to the formation of the corresponding ureas, which upon the action of Na alkoxides cyclize to 1-aryl-6-R-cytosine-5-carboxylates. The latter reacting with arylisocyanates according to the similar scheme give rise to 3,6-diaryl-5-methylpyrimido[4,5-d]pyrimidine-2,4,7(1H,3H,6H)-triones.

引用

页码：1035 / 1040

页数：6

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