Pyrene-labeled deoxyuridine and deoxyadenosine: fluorescent discriminating phenomena in their oligonucleotides

被引：43

作者：

Hwang, GT ^{[1
]}

Seo, YJ ^{[1
]}

Kim, BH ^{[1
]}

机构：

[1] Pohang Univ Sci & Technol, Div Mol & Life Sci, Dept Chem, Natl Res Lab, Pohang 790784, South Korea

来源：

TETRAHEDRON LETTERS | 2005年 / 46卷 / 09期

关键词：

fluorescence; excimer; interstrand stacking; nucleotides;

D O I：

10.1016/j.tetlet.2005.01.015

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Pyrene-labeled deoxyuridine (U-P) and deoxyadenosine (A(P)) units, which are substituted at the C-5 and C-8 positions, respectively, are fluorescent unnatural nucleosides. When duplexes are formed, these nucleobases feature strong and stable interstrand stacking interactions between the two pyrene units, which compensate for the loss of hydrogen bonding and induce characteristic pyrene excimer emissions. (C) 2005 Elsevier Ltd. All rights reserved.

引用

页码：1475 / 1477

页数：3

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