共 1 条
- [1] Protein quality control: from mechanism to diseaseEMBO Workshop, Costa de la Calma (Mallorca), Spain, April 28 – May 03, 2019Cell Stress and Chaperones, 2019, 24 : 1013 - 1026Harm H. KampingaMatthias P. MayerAxel Mogk
Protein quality control: from mechanism to disease EMBO Workshop, Costa de la Calma (Mallorca), Spain, April 28-May 03, 2019
被引：9
|作者：
Kampinga, Harm H.
[1
]
Mayer, Matthias P.
[2
]
Mogk, Axel
[2
]
机构：
[1] Univ Groningen, Univ Med Ctr Groningen, Dept Biomed Sci Cells & Syst, Groningen, Netherlands
[2] Heidelberg Univ, Ctr Mol Biol ZMBH, Neuenheimer Feld 282, D-69120 Heidelberg, Germany
来源：
关键词：
Protein quality control;
Protein homeostasis;
Chaperones;
Protein folding disease;
HEAT-SHOCK RESPONSE;
HSP70;
CHAPERONE;
C;
ELEGANS;
SPECIFICITY;
TRIGGERS;
DISAGGREGATION;
PROTEOSTASIS;
REGULATOR;
REVEALS;
BIOLOGY;
D O I：
10.1007/s12192-019-01040-9
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ;
090102 ;
摘要：
The cellular protein quality control machinery with its central constituents of chaperones and proteases is vital to maintain protein homeostasis under physiological conditions and to protect against acute stress conditions. Imbalances in protein homeostasis also are keys to a plethora of genetic and acquired, often age-related, diseases as well as aging in general. At the EMBO Workshop, speakers covered all major aspects of cellular protein quality control, from basic mechanisms at the molecular, cellular, and organismal level to medical translation. In this report, the highlights of the meeting will be summarized.
引用
收藏
页码：1013 / 1026
页数：14
相关论文