Current role of LC-MS in therapeutic drug monitoring

被引：99
作者：
Saint-Marcoux, Franck [1 ]
Sauvagge, Francois-Ludovic [1 ]
Marquet, Pierre [1 ]
机构：
[1] Univ Limoges Hosp, Dept Pharmacol Toxicol, INSERM, Unite U850, F-87042 Limoges, France
来源：
ANALYTICAL AND BIOANALYTICAL CHEMISTRY | 2007年 / 388卷 / 07期
关键词：
therapeutic drug monitoring; liquid chromatography; mass spectrometry;
D O I：
10.1007/s00216-007-1320-1
中图分类号：
Q5 [生物化学];
学科分类号：
071010 ; 081704 ;
摘要：
The role of liquid chromatography coupled with mass spectrometry (LC-MS) techniques in routine therapeutic drug monitoring activity is becoming increasingly important. This paper reviews LC-MS methods published in the last few years for certain classes of drugs subject to therapeutic drug monitoring: immunosuppressants, antifungal drugs, antiretroviral drugs, antidepressants and antipsychotics. For each class of compounds, we focussed on the most interesting methods and evaluated the current role of LC-MS in therapeutic drug monitoring.
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收藏
页码：1327 / 1349
页数：23
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