Clinical characteristics of a large cohort of patients with narcolepsy candidate for pitolisant: a cross-sectional study from the Italian PASS Wakix® Cohort

被引：0

作者：

Mutti, Carlotta ^{[1
]}

Brunetti, Valerio ^{[2
,3
]}

Figorilli, Michela ^{[4
]}

Liguori, Claudio ^{[5
,6
]}

Pizza, Fabio ^{[7
,8
]}

Proserpio, Paola ^{[9
]}

Sacco, Tommaso ^{[10
]}

Pedrazzi, Giuseppe ^{[11
]}

Lecomte, Isabelle ^{[12
]}

Blanchard, Nora ^{[13
]}

Agostoni, Elio Clemente ^{[9
]}

Bonanni, Enrica ^{[14
]}

Centonze, Diego ^{[6
,15
]}

Cicolin, Alessandro ^{[16
]}

Della Marca, Giacomo ^{[2
,3
]}

Ferini-Strambi, Luigi ^{[17
]}

Ferri, Raffaele ^{[18
]}

Gigli, Gian Luigi ^{[19
,20
]}

Izzi, Francesca ^{[5
]}

Liguori, Rocco ^{[7
,8
]}

Lodi, Raffaele ^{[7
,8
]}

Nobili, Lino ^{[21
,22
]}

Parrino, Liborio ^{[1
]}

Placidi, Fabio ^{[5
,6
]}

Puligheddu, Monica ^{[4
]}

Romigi, Andrea ^{[23
]}

Savarese, Maria Antonietta ^{[24
,25
]}

Terzaghi, Michele ^{[26
,27
]}

Plazzi, Giuseppe ^{[28
,29
]}

机构：

[1] Parma Univ Hosp, Sleep Disorders Ctr, Dept Gen & Specialist Med, Parma, Italy

[2] Fdn Policlin Univ A Gemelli IRCCS, Sleep Med Unit, UOC Neurol, Dipartimento Sci Invecchiamento Neurol Ortoped &, Largo A Gemelli 8, I-00168 Rome, Italy

[3] Univ Cattolica Sacro Cuore, Dept Neurosci, Largo Francesco Vito 1, I-00168 Rome, Italy

[4] Univ Cagliari, Sleep Disorder Res Ctr, Dept Med Sci & Publ Hlth, Cagliari, Italy

[5] Univ Hosp Rome Tor Vergata, Sleep Med Ctr, Neurol Unit, Rome, Italy

[6] Univ Roma Tor Vergata, Dept Syst Med, Rome, Italy

[7] Univ Bologna, Dipartimento Sci Biomed & Neuromotorie DIBINEM, Bologna, Italy

[8] IRCCS Ist Sci Neurol Bologna, Bologna, Italy

[9] ASST Grande Osped Metropolitano Niguarda, Dept Neurosci, Neurol & Stroke Unit, Sleep Med Ctr, Milan, Italy

[10] Bioprojet Italia, Med Dept, Via Giovan Battista Pirelli 11, Milan, Italy

[11] Univ Parma, Interdept Ctr Robust Stat RoSA, Dept Med & Surg, Unit Neurosci, Parma, Italy

[12] Bioprojet, 9 Rue Rameau, Paris, France

[13] Bioprojet, Pharmacovigilance Dept, 9 Rue Rameau, Paris, France

[14] Univ Pisa, Sleep Disorder Ctr, Pisa, Italy

[15] IRCCS Neuromed, Unit Neurol, Pozzilli, IS, Italy

[16] Univ Torino, Ctr Med Sonno, AOU Citta Salute & Sci, Dipartimento Neurosci Rita Levi Montalcini, Turin, Italy

[17] Univ Vita Salute San Raffaele, Milan, Italy

[18] Oasi Res Inst IRCCS, Sleep Res Ctr, Dept Neurol IC, Troina, EN, Italy

[19] Univ Udine, Dept Med DAME, Clin Neurol Unit, Udine, Italy

[20] Santa Maria della Misericordia Univ Hosp, Udine, Italy

[21] Univ Genoa, Dept Neurosci DINOGMI, Genoa, Italy

[22] Ist Giannina Gaslini, Child Neuropsychiat Unit, Genoa, Italy

[23] IRCCS Neuromed, Sleep Med Ctr, Pozzilli, IS, Italy

[24] Univ Bari Aldo Moro, Dept Basic Med Sci Neurosci & Sense Organs, Neurol Unit, Bari, Italy

[25] Univ Bari Aldo Moro, Dept Basic Med Sci Neurosci & Sense Organs, Stroke Ctr, Bari, Italy

[26] IRCCS Mondino Fdn, Unit Sleep Med & Epilepsy, Pavia, Italy

[27] Univ Pavia, Dept Brain & Behav Sci, Pavia, Italy

[28] Univ Modena & Reggio Emilia, Dipartimento Sci Biomed Metab & Neurosci, Modena, Italy

[29] IRCCS Ist Sci Neurol Bologna, Sleep Disorders Narcolepsy & CNS Hypersomnias Ctr, Bologna, Italy

来源：

NEUROLOGICAL SCIENCES | 2022年

关键词：

Polytherapy; Combined therapy; Pitolisant; Treatment; Sleepiness; Sleep; QUALITY-OF-LIFE; SODIUM OXYBATE; PHARMACOLOGICAL MANAGEMENT; SLEEP; HEALTH; MODAFINIL; CATAPLEXY; OUTCOMES; VERSION;

D O I：

暂无

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Introduction Narcolepsy is a chronic and rare hypersomnia of central origin characterized by excessive daytime sleepiness and a complex array of symptoms as well as by several medical comorbidities. With growing pharmacological options, polytherapy may increase the possibility of a patient-centered management of narcolepsy symptoms. The aims of our study are to describe a large cohort of Italian patients with narcolepsy who were candidates for pitolisant treatment and to compare patients' subgroups based on current drug prescription (drug-naive patients in whom pitolisant was the first-choice treatment, switching to pitolisant from other monotherapy treatments, and adding on in polytherapy). Methods We conducted a cross-sectional survey based on Italian data from the inclusion visits of the Post Authorization Safety Study of pitolisant, a 5-year observational, multicenter, international study. Results One hundred ninety-one patients were enrolled (76.4% with narcolepsy type 1 and 23.6% with narcolepsy type 2). Most patients (63.4%) presented at least one comorbidity, mainly cardiovascular and psychiatric. Pitolisant was prescribed as an add-on treatment in 120/191 patients (62.8%), as switch from other therapies in 42/191 (22.0%), and as a first-line treatment in 29/191 (15.2%). Drug-naive patients presented more severe sleepiness, lower functional status, and a higher incidence of depressive symptoms. Conclusion Our study presents the picture of a large cohort of Italian patients with narcolepsy who were prescribed with pitolisant, suggesting that polytherapy is highly frequent to tailor a patient-centered approach.

引用

页数：12

共 39 条

[1] Clinical and Therapeutic Aspects of Childhood Narcolepsy-Cataplexy: A Retrospective Study of 51 Children [J].