PP2A's restraint of mTOR is critical for Treg cell activity

被引：8

作者：

Delgoffe, Greg M. ^{[1
,2
]}

机构：

[1] Univ Pittsburgh, Inst Canc, Tumor Microenvironm Ctr, Pittsburgh, PA USA

[2] Univ Pittsburgh, Dept Immunol, Pittsburgh, PA USA

来源：

NATURE IMMUNOLOGY | 2016年 / 17卷 / 05期

关键词：

PHOSPHATASE PP2A; KINASE;

D O I：

10.1038/ni.3442

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Regulatory T cells must limit activation of the metabolic checkpoint kinase mTOR to maintain their identity. The lipid ceramide serves a unique role in this process by inducing phosphatase PP2A-mediated inhibition of the mTORC1 complex.

引用

页码：478 / 479

页数：3

共 44 条

[31] S-Equol ameliorates insulin secretion failure through Chrebp/Txnip signaling via modulating PKA/PP2A activities
Chen, Ka
Lang, Hedong
Wang, Li
Liu, Kai
Zhou, Yong
Mi, Mantian
NUTRITION & METABOLISM, 2020, 17 (01)
[32] CIP2A- and SETBP1-mediated PP2A inhibition reveals AKT S473 phosphorylation to be a new biomarker in AML
Lucas, Claire M.
Scott, Laura J.
Carmell, Natasha
Holcroft, Alison K.
Hills, Robert K.
Burnett, Alan K.
Clark, Richard E.
BLOOD ADVANCES, 2018, 2 (09) : 964 - 968
[33] An AMBRA1, ULK1 and PP2A regulatory network regulates cytotoxic T cell differentiation via TFEB activation
Migliore, Loredana
Cianfanelli, Valentina
Zevolini, Fabrizia
Gesualdo, Monica
Marzuoli, Leandro
Patrussi, Laura
Ulivieri, Cristina
Marotta, Giuseppe
Cecconi, Francesco
Finetti, Francesca
Baldari, Cosima T.
SCIENTIFIC REPORTS, 2024, 14 (01):
[34] Combination of dasatinib and okadaic acid induces apoptosis and cell cycle arrest by targeting protein phosphatase PP2A in chronic myeloid leukemia cells
Ozel, Buket
Kipcak, Sezgi
Avci, Cigir Biray
Gunduz, Cumhur
Saydam, Guray
Aktan, Cagdas
Gunel, Nur Selvi
MEDICAL ONCOLOGY, 2022, 39 (04)
[35] Regulation of the stability and activity of CDC25A and CDC25B by protein phosphatase PP2A and 14-3-3 binding
Kohama, Yuri
Saito, Megumi
Yada, Mizue
Sakurai, Hiroshi
CELLULAR SIGNALLING, 2019, 54 : 10 - 16
[36] Integrated Pathways of COX-2 and mTOR: Roles in Cell Sensing and Alzheimer's Disease
Tyagi, Arti
Kamal, Mohammad A.
Poddar, Nitesh Kumar
FRONTIERS IN NEUROSCIENCE, 2020, 14
[37] IL-17A's role in exacerbating radiation-induced lung injury: Autophagy impairment via the PP2A-mTOR pathway
Liu, Liangzhong
Yi, Guangming
Li, Xiaohong
Chen, Cai
Chen, Kehong
He, Hengqiu
Li, Jinjin
Cai, Fanghao
Peng, Yuan
Yang, Zhenzhou
Zhang, Xiaoyue
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH, 2025, 1872 (01):
[38] Rapamycin inhibits BAFF-stimulated cell proliferation and survival by suppressing mTOR-mediated PP2A-Erk1/2 signaling pathway in normal and neoplastic B-lymphoid cells
Zeng, Qingyu
Zhang, Hai
Qin, Jiamin
Xu, Zhigang
Gui, Lin
Liu, Beibei
Liu, Chunxiao
Xu, Chong
Liu, Wen
Zhang, Shuangquan
Huang, Shile
Chen, Long
CELLULAR AND MOLECULAR LIFE SCIENCES, 2015, 72 (24) : 4867 - 4884
[39] Cryptotanshinone Prevents the Binding of S6K1 to mTOR/Raptor Leading to the Suppression of mTORC1-S6K1 Signaling Activity and Neoplastic Cell Transformation
Jeoung, Nam Ho
Jeong, Ji Yun
Kang, Bong Seok
JOURNAL OF CANCER PREVENTION, 2021, 26 (02) : 145 - 152
[40] Tumor Progression Locus 2 (Tpl2) Activates the Mammalian Target of Rapamycin (mTOR) Pathway, Inhibits Forkhead Box P3 (FoxP3) Expression, and Limits Regulatory T Cell (Treg) Immunosuppressive Functions
Li, Xin
Acuff, Nicole V.
Peeks, Angela R.
Kirkland, Rebecca
Wyatt, Kara D.
Nagy, Tamas
Watford, Wendy T.
JOURNAL OF BIOLOGICAL CHEMISTRY, 2016, 291 (32) : 16802 - 16815

← 1 2 3 4 5 →