PP2A's restraint of mTOR is critical for Treg cell activity

被引：8
|
作者：
Delgoffe, Greg M. [1 ,2 ]
机构：
[1] Univ Pittsburgh, Inst Canc, Tumor Microenvironm Ctr, Pittsburgh, PA USA
[2] Univ Pittsburgh, Dept Immunol, Pittsburgh, PA USA
来源：
NATURE IMMUNOLOGY | 2016年 / 17卷 / 05期
关键词：
PHOSPHATASE PP2A; KINASE;
D O I：
10.1038/ni.3442
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Regulatory T cells must limit activation of the metabolic checkpoint kinase mTOR to maintain their identity. The lipid ceramide serves a unique role in this process by inducing phosphatase PP2A-mediated inhibition of the mTORC1 complex.
引用
收藏
页码：478 / 479
页数：3
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