PP2A's restraint of mTOR is critical for Treg cell activity

被引：9

作者：

Delgoffe, Greg M. ^{[1
,2
]}

机构：

[1] Univ Pittsburgh, Inst Canc, Tumor Microenvironm Ctr, Pittsburgh, PA USA

[2] Univ Pittsburgh, Dept Immunol, Pittsburgh, PA USA

来源：

NATURE IMMUNOLOGY | 2016年 / 17卷 / 05期

关键词：

PHOSPHATASE PP2A; KINASE;

D O I：

10.1038/ni.3442

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Regulatory T cells must limit activation of the metabolic checkpoint kinase mTOR to maintain their identity. The lipid ceramide serves a unique role in this process by inducing phosphatase PP2A-mediated inhibition of the mTORC1 complex.

引用

页码：478 / 479

页数：3

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