Transplantation of micro- and macroencapsulated piglet islets into mice and monkeys

被引：88

作者：

Elliott, RB

Escobar, L

Calafiore, R

Basta, G

Garkavenko, O

Vasconcellos, A

Bambra, C

机构：

[1] Living Cell Technol, Auckland, New Zealand

[2] Univ Perugia, I-06100 Perugia, Italy

[3] Maccine Ltd, Singapore, Singapore

来源：

TRANSPLANTATION PROCEEDINGS | 2005年 / 37卷 / 01期

关键词：

D O I：

10.1016/j.transproceed.2004.12.198

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Neonatal porcine islets within alginate microcapsules transplanted intraperitoneally (IP) or within semi-permeable macrocapsules (TheraCyte) and transplanted subcutaneously (SC) survive and reverse diabetes for up to 16 weeks in diabetic autoimmune nonobese diabetic (NOD) mice. The islets in microcapsules transplanted IP into nondiabetic cynomolgus monkeys survived for 8 weeks. Similar results were shown with islets transplanted in TheraCytes. Neither species showed adverse effects or evidence of infection with porcine endogenous retroviruses or other endemic pig viruses. Proof of principle is illustrated for successful xenotransplantation in humans.

引用

页码：466 / 469

页数：4

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