Mucins and their receptors in chronic lung disease

被引：30

作者：

Denneny, Emma ^{[1
]}

Sahota, Jagdeep ^{[1
]}

Beatson, Richard ^{[2
]}

Thornton, David ^{[3
]}

Burchell, Joy ^{[2
]}

Porter, Joanna ^{[1
]}

机构：

[1] UCL, Ctr Inflammat & Tissue Repair, Rayne Inst, Leukocyte Trafficking Lab,UCL Resp, 5 Univ St, London WC1E 6JF, England

[2] Kings Coll London, Guys Hosp, Div Canc Studies, Breast Canc Biol Grp, London, England

[3] Univ Manchester, Manchester Acad Hlth Sci Ctr, Fac Biol, Wellcome Trust Ctr Cell Matrix Res,Sch Biol Sci, Manchester, Lancs, England

来源：

CLINICAL & TRANSLATIONAL IMMUNOLOGY | 2020年 / 9卷 / 03期

基金：

英国医学研究理事会;

关键词：

glycan-binding protein; glycosylation; immunology; mucin; pulmonary; MUC1; GLYCOSYLATION; ACTIVATION; MEMBRANE; GLYCANS; BINDING; GROWTH; GLYCOBIOLOGY; INFLAMMATION; ENGAGEMENT;

D O I：

10.1002/cti2.1120

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

There is growing recognition that mucus and mucin biology have a considerable impact on respiratory health, and subsequent global morbidity and mortality. Mucins play a critical role in chronic lung disease, not only by providing a physical barrier and clearing pathogens, but also in immune homeostasis. The aim of this review is to familiarise the reader with the role of mucins in both lung health and disease, with particular focus on function in immunity, infection and inflammation. We will also discuss their receptors, termed glycan-binding proteins, and how they provide an attractive prospect for therapeutic intervention.

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页数：14

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