ELEVATED RISK OF PAPILLARY THYROID CANCER IN KOREAN PATIENTS WITH HASHIMOTO'S THYROIDITIS

被引：126

作者：

Kim, Kyung Won ^{[1
,2
]}

Park, Young Joo ^{[1
,3
]}

Kim, Eun Hye ^{[3
]}

Park, So Yeon ^{[4
,5
]}

Park, Do Joong

Ahn, Soon-Hyun ^{[8
,9
]}

Park, Do Joon ^{[1
,6
,7
]}

Jang, Hak C. ^{[1
,3
]}

Cho, Bo Youn ^{[1
]}

机构：

[1] Seoul Natl Univ, Coll Med, Dept Internal Med, Seoul 151, South Korea

[2] Seoul Natl Univ Hosp, Healthcare Syst Gangnam Ctr, Seoul 110744, South Korea

[3] Seoul Natl Univ, Bundang Hosp, Dept Internal Med, Songnam, South Korea

[4] Seoul Natl Univ, Coll Med, Dept Pathol, Seoul 151, South Korea

[5] Seoul Natl Univ, Bundang Hosp, Dept Pathol, Songnam, South Korea

[6] Seoul Natl Univ, Coll Med, Dept Surg, Seoul, South Korea

[7] Seoul Natl Univ, Bundang Hosp, Dept Surg, Songnam, South Korea

[8] Seoul Natl Univ, Coll Med, Dept Otorhinolaryngol, Seoul, South Korea

[9] Seoul Natl Univ, Bundang Hosp, Dept Otorhinolaryngol, Songnam, South Korea

来源：

HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK | 2011年 / 33卷 / 05期

关键词：

Hashimoto's thyroiditis; thyroid cancer; thyrotropin; thyroid-stimulating hormone; papillary thyroid cancer; STIMULATING HORMONE-LEVEL; DIETARY IODINE INTAKE; SERUM TSH; HIGH PREVALENCE; CARCINOMA; ASSOCIATION; MALIGNANCY; NODULES; POPULATION; MANAGEMENT;

D O I：

10.1002/hed.21518

中图分类号：

R76 [耳鼻咽喉科学];

学科分类号：

100213 ;

摘要：

Background. Hashimoto's thyroiditis (HT) and higher levels of thyroid-stimulating hormone (TSH) have been proposed as risk factors for papillary thyroid cancer (PTC), but this issue is still being debated. The purpose of this study was whether HT was related to the risk of PTC over TSH. Methods. We enrolled 1329 patients (1028 with PTC, 52 with follicular thyroid cancer, and 249 with benign disease) of 1490 patients who underwent thyroidectomy. Results. The TSH concentration was not different among patients with PTC or benign disease. Our study showed that men (odds ratio [OR] 1.54; p = .049) and the presence of HT (OR 2.96; p <. 001) increased the risk of PTC. Moreover, HT was associated with multifocal cancer (p = .005) and smaller tumor size (p = .031), but it did not influence the extrathyroidal invasion or nodal metastasis. Conclusion. Clinicians who deal with thyroid nodules should pay particular attention to HT because it is a stronger predictor for PTC than other risk factors. (C) 2010 Wiley Periodicals, Inc. Head Neck 33: 691-695, 2011

引用

页码：691 / 695

页数：5

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