Bacteriophage Assembly

被引:103
作者
Aksyuk, Anastasia A. [1 ]
Rossmann, Michael G. [1 ]
机构
[1] Purdue Univ, Dept Biol Sci, W Lafayette, IN 47907 USA
来源
VIRUSES-BASEL | 2011年 / 3卷 / 03期
基金
美国国家科学基金会; 美国国家卫生研究院;
关键词
bacteriophage; assembly; macromolecular complex; genome packaging; maturation; COAT PROTEIN STRUCTURES; X-RAY CRYSTALLOGRAPHY; ALPHA-LYTIC PROTEASE; CRYSTAL-STRUCTURE; 3-DIMENSIONAL STRUCTURE; GENETIC-CONTROL; SCAFFOLDING PROTEINS; HUMAN ADENOVIRUS; BACILLUS-SUBTILIS; BASEPLATE MORPHOGENESIS;
D O I
10.3390/v3030172
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
Bacteriophages have been a model system to study assembly processes for over half a century. Formation of infectious phage particles involves specific protein-protein and protein-nucleic acid interactions, as well as large conformational changes of assembly precursors. The sequence and molecular mechanisms of phage assembly have been elucidated by a variety of methods. Differences and similarities of assembly processes in several different groups of bacteriophages are discussed in this review. The general principles of phage assembly are applicable to many macromolecular complexes.
引用
收藏
页码:172 / 203
页数:32
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