Recent Advances on the Role of Brain-Derived Neurotrophic Factor (BDNF) in Neurodegenerative Diseases

被引：141

作者：

Azman, Khairunnuur Fairuz ^{[1
]}

Zakaria, Rahimah ^{[1
]}

机构：

[1] Univ Sains Malaysia, Sch Med Sci, Dept Physiol, Kubang Kerian 16150, Kelantan, Malaysia

来源：

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2022年 / 23卷 / 12期

关键词：

BDNF; neurodegeneration; Alzheimer; Parkinson; Huntington; amyotrophic lateral sclerosis; MILD COGNITIVE IMPAIRMENT; ALZHEIMERS-DISEASE; PARKINSONS-DISEASE; VAL66MET POLYMORPHISM; MOLECULAR-MECHANISMS; HUNTINGTONS-DISEASE; SERUM-LEVELS; MOUSE MODEL; DECREASED-LEVELS; MESSENGER-RNA;

D O I：

10.3390/ijms23126827

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Neurotrophins, such as brain-derived neurotrophic factor (BDNF), are essential for neuronal survival and growth. The signaling cascades initiated by BDNF and its receptor are the key regulators of synaptic plasticity, which plays important role in learning and memory formation. Changes in BDNF levels and signaling pathways have been identified in several neurodegenerative diseases, including Alzheimer's disease, Parkinson's disease, and Huntington's disease, and have been linked with the symptoms and course of these diseases. This review summarizes the current understanding of the role of BDNF in several neurodegenerative diseases, as well as the underlying molecular mechanism. The therapeutic potential of BDNF treatment is also discussed, in the hope of discovering new avenues for the treatment of neurodegenerative diseases.

引用

页数：24

共 155 条

[41] A new brain-derived neurotrophic factor transcript and decrease in brain-derived neurotrophic factor transcripts 1, 2 and 3 in Alzheimer's disease parietal cortex [J].

Garzon, D ;

Yu, GH ;

Fahnestock, M .

JOURNAL OF NEUROCHEMISTRY, 2002, 82 (05) :1058-1064

[42] 2019 Alzheimer's disease facts and figures [J].

Gaugler, Joseph ;

James, Bryan ;

Johnson, Tricia ;

Marin, Allison ;

Weuve, Jennifer .

ALZHEIMERS & DEMENTIA, 2019, 15 (03) :321-387

[43] BDNF, TNFα, HSP90, CFH, and IL-10 Serum Levels in Patients with Early or Late Onset Alzheimer's Disease or Mild Cognitive Impairment [J].

Gezen-Ak, Duygu ;

Dursun, Erdinc ;

Hanagasi, Hasmet ;

Bilgic, Basar ;

Lohman, Ebba ;

Araz, Omur Selin ;

Atasoy, Irem L. ;

Alaylioglu, Merve ;

Onal, Burak ;

Gurvit, Hakan ;

Yilmazer, Selma .

JOURNAL OF ALZHEIMERS DISEASE, 2013, 37 (01) :185-195

[44] BDNF Val66Met Polymorphism Is Associated With Motor Recovery After Rehabilitation in Progressive Multiple Sclerosis Patients [J].

Giordano, Antonino ;

Clarelli, Ferdinando ;

Cannizzaro, Miryam ;

Mascia, Elisabetta ;

Santoro, Silvia ;

Sorosina, Melissa ;

Ferre, Laura ;

Leocani, Letizia ;

Esposito, Federica .

FRONTIERS IN NEUROLOGY, 2022, 13

[45] Cellular and molecular mechanisms regulating neuronal growth by brain-derived neurotrophic factor [J].

Gonzalez, Andres ;

Moya-Alvarado, Guillermo ;

Gonzalez-Billaut, Christian ;

Bronfman, Francisca C. .

CYTOSKELETON, 2016, 73 (10) :612-628

[46] Aberrant heart rate and brainstem brain-derived neurotrophic factor (BDNF) signaling in a mouse model of Huntington's disease [J].

Griffioen, Kathleen J. ;

Wan, Ruiqian ;

Brown, Tashalee R. ;

Okun, Eitan ;

Camandola, Simonetta ;

Mughal, Mohamed R. ;

Phillips, Terry M. ;

Mattson, Mark P. .

NEUROBIOLOGY OF AGING, 2012, 33 (07) :1481.e1-1481.e5

[47] Silencing of LncRNA BDNF-AS attenuates Aβ25-35-induced neurotoxicity in PC12 cells by suppressing cell apoptosis and oxidative stress [J].

Guo, Cong-Cong ;

Jiao, Chun-hong ;

Gao, Zhen-Mei .

NEUROLOGICAL RESEARCH, 2018, 40 (09) :795-804

[48] Evaluation of Biochemical and Epigenetic Measures of Peripheral Brain-Derived Neurotrophic Factor (BDNF) as a Biomarker in Huntington's Disease Patients [J].

Gutierrez, Ashley ;

Corey-Bloom, Jody ;

Thomas, Elizabeth A. ;

Desplats, Paula .

FRONTIERS IN MOLECULAR NEUROSCIENCE, 2020, 12

[49]

Hayashi Yuki, 2015, Advances in Biological Regulation, V60, P95, DOI [10.1016/j.jbior.2015.10.006, 10.1016/j.jbior.2015.10.006]

[50] BDNF levels and nigrostriatal degeneration in "drug naive" Parkinson's disease patients. An "in vivo" study using I-123-FP-CIT SPECT [J].

Hernandez-Vara, J. ;

Saez-Francas, N. ;

Lorenzo-Bosquet, C. ;

Corominas-Roso, M. ;

Cuberas-Borros, G. ;

Lucas-Del Pozo, S. ;

Carter, S. ;

Armengol-Bellapart, M. ;

Castell-Conesa, J. .

PARKINSONISM & RELATED DISORDERS, 2020, 78 :31-35

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